Contrast-Enhanced Ultrasonography of Pancreatic Carcinoma: Correlation with Pathologic Findings

Ultrasound in Medicine & Biology
Yanjie WangWei Yang

Abstract

We concluded that contrast-enhanced ultrasound (CEUS) has clinical value in identifying the pathologic changes of pancreatic carcinomas. Forty-three patients diagnosed with pancreatic carcinoma through surgery were retrospectively investigated. CEUS examinations were performed on all patients before surgery. Enhancement patterns on CEUS were observed. Time-intensity curves of CEUS were generated for the regions of interest in the pancreas, and quantitative parameters were obtained. Resected cancer specimens were stained with hematoxylin and eosin for histologic analysis, and the microvascular density (MVD) of the specimens was determined by CD34 immunohistochemical staining. Enhancement patterns of CEUS were compared with histopathologic findings in pancreatic carcinomas. Correlations between time-intensity curve parameters and microvascular density were analyzed. Twenty cases manifested centripetal enhancement, and 23 cases, global enhancement. The amount of tumor necrosis or mucus in the centripetally enhanced pancreatic carcinomas was greater than that in the globally enhanced pancreatic carcinomas (p = 0.027). Thirty-eight of 43 (88.4%) pancreatic carcinomas manifested hypo-enhancement with a maximum intensity (IMAX) <90%. ...Continue Reading

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Citations

Jan 6, 2018·European Radiology·Khoschy SchawkatJohannes T Heverhagen
Aug 30, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yanjie WangWei Wu
Aug 20, 2019·Journal of Medical Ultrasonics·Atsushi SofuniTakao Itoi
Jun 3, 2021·Diagnostics·Tommaso Vincenzo BartolottaAdele Taibbi

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