Contrast-enhanced ultrasonography of the pancreas shows impaired perfusion in pancreas insufficient cystic fibrosis patients

BMC Medical Imaging
Trond EngjomGeorg Dimcevski

Abstract

Perfusion assessment of the pancreas is challenging and poorly evaluated. Pancreatic affection is a prevalent feature of cystic fibrosis (CF). Little is known about pancreatic perfusion in CF. We aimed to assess pancreatic perfusion by contrast-enhanced ultrasound (CEUS) analysed in the bolus-and-burst model and software. We performed contrast enhanced ultrasound of the pancreas in 25 CF patients and 20 healthy controls. Perfusion data was analysed using a dedicated perfusion model providing the mean capillary transit-time (MTT), blood flow (BF) and blood-volume (BV). CF patients were divided according to exocrine function. The pancreas insufficient CF patients had longer MTT (p ≤ 0.002), lower BF (p < 0.001) and lower BV (p < 0.05) compared to the healthy controls and sufficient CF patients. Interrater analysis showed substantial agreement for the analysis of mean transit time. The bolus-and-burst method used on pancreatic CEUS-examinations demonstrates reduced perfusion in CF patients with pancreas affection. The perfusion model and software requires further optimization and standardization to be clinical applicable for the assessment of pancreatic perfusion.

References

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Citations

Aug 11, 2020·Current Opinion in Pediatrics·Zachary M Sellers
Apr 17, 2019·Journal of Applied Physiology·David F Wilson, Franz M Matschinsky
Jan 13, 2021·Physiological Measurement·Elisabeth K SteinsvikOdd Helge Gilja
Aug 26, 2021·Pediatric Radiology·Doris FrankeJudy H Squires

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Software Mentioned

DCE
SPSS
US
MATLAB
SigmaPlot
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