Contrast-enhanced ultrasound imaging of the vasa vasorum: from early atherosclerosis to the identification of unstable plaques

JACC. Cardiovascular Imaging
D StaubSteven B Feinstein

Abstract

Proliferation of the adventitial vasa vasorum (VV) is inherently linked with early atherosclerotic plaque development and vulnerability. Recently, direct visualization of arterial VV and intraplaque neovascularization has emerged as a new surrogate marker for the early detection of atherosclerotic disease. This clinical review focuses on contrast-enhanced ultrasound (CEUS) as a noninvasive application for identifying and quantifying carotid and coronary artery VV and intraplaque neovascularization. These novel approaches could potentially impact the clinician's ability to identify individuals with premature cardiovascular disease who are at high risk. Once clinically validated, the uses of CEUS may provide a method to noninvasively monitor therapeutic interventions. In the future, the therapeutic use of CEUS may include ultrasound-directed, site-specific therapies using microbubbles as vehicles for drug and gene delivery systems. The combined applications for diagnosis and therapy provide unique opportunities for clinicians to image and direct therapy for individuals with vulnerable lesions.

References

Jan 1, 1979·Blood Vessels·D D Heistad, M L Marcus
May 16, 1998·The Journal of Clinical Investigation·H M KwonA Lerman
Dec 12, 2003·The New England Journal of Medicine·Frank D KolodgieRenu Virmani
Apr 6, 2004·Journal of the American College of Cardiology·Osamu HondaHisao Ogawa
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steven B Feinstein
Oct 13, 2004·Circulation·Rohit KhuranaMichael Simons
Nov 4, 2004·Cerebrovascular Diseases·P-J TouboulUNKNOWN Advisory Board of the 3rd Watching the Risk Symposium 2004, 13th European Stroke Conference
Feb 25, 2005·Current Atherosclerosis Reports·Stéphane CarlierMorteza Naghavi
Apr 18, 2006·Ultrasound in Medicine & Biology·David E GoertzA F W van der Steen
May 11, 2006·Circulation·Pedro R MorenoValentin Fuster
Jul 18, 2006·Journal of the American College of Cardiology·Steven B Feinstein
Sep 9, 2006·Current Opinion in Lipidology·Karen S Moulton
Oct 14, 2006·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Martijn E FrijlinkAntonius F W van der Steen
Dec 23, 2006·The International Journal of Cardiovascular Imaging·Pierre-Jean TouboulUNKNOWN PARC-AALA Investigators
Jan 11, 2007·Journal of Vascular Surgery·Benjamin J DunmoreNicholas P J Brindle
Mar 6, 2007·Atherosclerosis·Michael KoutouzisZenon S Kyriakides
Aug 9, 2007·Ultrasound in Medicine & Biology·David E GoertzAntonius F W van der Steen
Feb 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W S KerwinT S Hatsukami
Mar 29, 2008·Journal of the American College of Cardiology·Judith C SluimerAnn-Pascale J Bijnens
May 23, 2008·International Journal of Cardiology·Theodore G PapaioannouChristodoulos Stefanadis
May 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Jean-Christophe CornilyZahi A Fayad
Jul 12, 2008·Stroke; a Journal of Cerebral Circulation·Patrizio PratiPierre-Jean Touboul
Jul 25, 2008·Nature Clinical Practice. Cardiovascular Medicine·Juan F Granada, Steven B Feinstein
Aug 19, 2008·Current Atherosclerosis Reports·Blai Coll, Steven B Feinstein
Mar 25, 2009·The Journal of Pathology·Judith C Sluimer, Mat J Daemen
Mar 31, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M F GiannoniF B Valentini
Apr 25, 2009·Cerebrovascular Diseases·Mark PiedraJonathan R Lindner
Nov 17, 2009·The New England Journal of Medicine·Allen J TaylorMark Turco

❮ Previous
Next ❯

Citations

Jun 19, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jie SunYou-Bin Deng
May 10, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gary R Small, Terrence D Ruddy
Mar 15, 2011·European Heart Journal·Jean-Baptiste MichelGerard Pasterkamp
Nov 12, 2010·QJM : Monthly Journal of the Association of Physicians·H Pieringer, M Pichler
Aug 7, 2012·Interface Focus·Chris L de KorteAnton F W van der Steen
Feb 12, 2011·Vascular Medicine·Luis H ErasoEmile R Mohler
Dec 24, 2011·AJR. American Journal of Roentgenology·Sasan PartoviDaniel Staub
May 8, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Francois T H YuXucai Chen
May 20, 2014·International Journal of Cardiology·Adrienne MüllerStefanie D Krämer
Nov 20, 2013·European Heart Journal Cardiovascular Imaging·Arend F L SchinkelEric J G Sijbrands
Mar 5, 2014·Journal of Cardiovascular Translational Research·Travis P Sharkey-ToppenSubha V Raman
May 6, 2015·International Journal of Molecular Sciences·David C Steinl, Beat A Kaufmann
Jan 27, 2016·Cardiovascular Drugs and Therapy·Jeremy D KratzSascha N Goonewardena
Nov 30, 2013·Neurologic Clinics·Joseph V Fritz
Aug 6, 2013·Ultrasound in Medicine & Biology·Renate W BoekhovenMarcel C M Rutten
Feb 22, 2012·Ultrasound in Medicine & Biology·Gerrit L ten KateAntonius F W van der Steen
Jul 25, 2015·The International Journal of Cardiovascular Imaging·Arend F L SchinkelDaniel Staub
Jul 22, 2011·Ultrasound in Medicine & Biology·Paul S SheeranPaul A Dayton
Oct 27, 2010·Current Problems in Cardiology·Gerrit L ten KateArend F L Schinkel
Jan 23, 2016·Radiology Research and Practice·Sunny GoelOn Chen
May 7, 2011·British Journal of Pharmacology·Gregory A PayneJohnathan D Tune
May 8, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Jianguo MaXiaoning Jiang
Nov 28, 2015·Neuroimaging Clinics of North America·Jie Sun, Thomas S Hatsukami
Jul 15, 2015·IEEE Transactions on Medical Imaging·Iason Zacharias ApostolakisElisa E Konofagou
Jun 6, 2015·Clinical Physiology and Functional Imaging·Tomas JogestrandHelene Zachrisson
Jun 26, 2014·Journal of Magnetic Resonance Imaging : JMRI·Andrew L WentlandThomas M Grist
Jun 17, 2014·Echocardiography·Uchechukwu K A SampsonSteve B Feinstein
Jun 12, 2012·Atherosclerosis·Augusto GallinoPeter Libby
Jul 17, 2015·BioMed Research International·Gianfranco VarettoPietro Rispoli
Feb 24, 2015·Journal of cardiology·Marco MagnoniPaolo G Camici
Jul 25, 2013·Atherosclerosis·Stijn C H van den OordArend F L Schinkel
Nov 26, 2013·Atherosclerosis·Pranvera IbrahimiMichael Y Henein
Feb 26, 2015·AJR. American Journal of Roentgenology·Farhood Saremi, Stephan Achenbach
Apr 27, 2016·Current Atherosclerosis Reports·Raf H M van HoofM Eline Kooi
Aug 5, 2016·Cell Proliferation·Minjia DaiWeidong Tian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.