Contrast in cytokine expression between patients with monoclonal gammopathy of undetermined significance or multiple myeloma

Leukemia
K A DonovanJ A Lust

Abstract

We investigated whether differences in IL-6 and IL-1beta expression could be detected in monoclonal plasma cells from patients with MGUS or MM. Expression of IL-6 and IL-1beta in bone marrow cells was determined using cell sorting to enrich for plasma cells followed by reverse transcriptase/polymerase chain reaction (RT/PCR). Nineteen patients (six MGUS, two primary amyloid (AL), 11 MM) were studied. IL-6 mRNA expression was detectable in the sorted CD38+/CD45- plasma cell populations from 0/6 MGUS, 0/2 AL and 5/11 MM patients. All five MM patients with autocrine IL-6 expression demonstrated an elevated plasma cell labeling index. IL-1beta mRNA was detectable in the sorted CD38+/CD45- plasma cell populations from 1/6 MGUS, 0/2 AL and 10/11 MM patients. In situ hybridization (ISH) confirmed that the IL-1beta producing cells were plasma cells. In conclusion, autocrine production of IL-6 parallels a high labeling index and aberrant expression of IL-1beta correlates with the diagnosis of MM. Follow-up of IL-1beta-positive MGUS patients will determine whether aberrant expression of IL-1beta will predict those MGUS patients that will eventually progress to MM.

Citations

Jul 6, 2000·Current Opinion in Hematology·N N Sjak-ShieJ R Berenson
Feb 21, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yuning XiongJohn A Lust
Jan 8, 2000·Hematology/oncology Clinics of North America·J A Lust, K A Donovan
Aug 12, 2006·Mayo Clinic Proceedings·Martha Q LacyRobert A Kyle
Jan 8, 2000·Hematology/oncology Clinics of North America·T E Witzig
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clara CesanaEnrica Morra
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·J A Lust, K A Donovan
May 13, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Anoop MistryJeroen C H van der Hilst
Jun 13, 2019·International Journal of Molecular Sciences·Alessandro AllegraSebastiano Gangemi
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sanjai SharmaAlan Lichtenstein
Aug 28, 2021·International Journal of Molecular Sciences·Giuseppe MurdacaSebastiano Gangemi

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