Contrast-induced nephropathy: pharmacological prophylaxis

Kidney International. Supplement
C Briguori, G Marenzi

Abstract

Contrast media-associated acute renal failure represents the third most common cause of in-hospital renal function deterioration after decreased renal perfusion and post-operative renal insufficiency. Although generally benign, this complication is associated with a mortality rate ranging from 3.8 to 64%, depending on the increase of creatinine concentration. Multiple drugs have been tested in an attempt to prevent this complication. Central to the pathophysiology of contrast-induced nephrotoxicity (CIN) is an alteration in renal hemodynamics. In an effort to reverse these hemodynamic changes, vasodilators and diuretics have been tested as prophylactic drugs. However, their effectiveness has not been confirmed. Recently, considerable interest has resulted from the initial positive data on the effectiveness of prophylactic administration of antioxidant compounds, such as acetylcysteine and ascorbic acid. In this review, we focus on the effectiveness of pharmacologic therapies for preventing CIN.

References

Oct 1, 1992·The Journal of Surgical Research·K A HallR L Misiorowski
Dec 1, 1990·Kidney International·K B MarguliesJ C Burnett
Jan 1, 1984·Clinical Cardiology·J P Pourrat, P Douste-Blazy
Apr 1, 1995·Radiology·R E KatholiC L Lucore
Nov 1, 1995·Journal of the American Society of Nephrology : JASN·D RussoL De Nicola
Mar 1, 1996·International Journal of Cardiology·A KapoorR Bajaj
Apr 8, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B R KurnikL S Weisberg
May 18, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M TariqA Al Khader
May 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C M ErleyT Risler
Nov 30, 1999·Journal of the American College of Cardiology·M GareM Mosseri
Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J A KochU Mödder
Apr 12, 2000·Kidney International·A WangS J Schwab
Jul 20, 2000·The New England Journal of Medicine·M TepelW Zidek
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H IzzedineG Deray
Jul 18, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·H MadyoonV Mathur
Jan 26, 2002·The American Journal of Cardiology·Larry J Diaz-SandovalDouglas W Losordo
Nov 1, 1995·American Journal of Therapeutics·Lawrence GurkowskiThomas Wiegmann
Jul 11, 2002·Journal of the American College of Cardiology·Carlo BriguoriBruno Ricciardelli
Aug 20, 2002·AJR. American Journal of Roentgenology·Abbas A ChamsuddinDavid W Hunter
Oct 24, 2002·Journal of the American College of Cardiology·Kou Gi ShyuPeiliang Kuan
Oct 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aditya KapoorNakul Sinha
Nov 1, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Suhail AllaqabandTanvir K Bajwa
Feb 21, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Fernando BoccalandroStefano Sdringola
Mar 13, 2003·Kidney International·Samuel N HeymanSeymor Rosen
Jun 25, 2003·Journal of the American College of Cardiology·Christopher S R BakerCharles J Knight
Aug 29, 2003·Lancet·Rainer BirckClaude Braun
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Gregg W StoneUNKNOWN CONTRAST Investigators
Dec 9, 2003·American Heart Journal·J Bradley OldemeyerDaniel E Hilleman
Dec 17, 2003·The American Journal of Cardiology·Daniel W IsenbargerPatrick G O'Malley

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Citations

Oct 25, 2012·Internal and Emergency Medicine·Giancarlo MarenziMara Rubino
Sep 12, 2012·American Journal of Nephrology·Athanasios DiamantopoulosNikos E Tsopanoglou
Jan 11, 2008·Journal of the American Society of Nephrology : JASN·Yukiyo YokomakuAtsunori Kashiwagi
Nov 12, 2013·Advances in Chronic Kidney Disease·Junjie ChenSamuel A Wickline
Jan 9, 2016·Clinical and Experimental Pharmacology & Physiology·Barry Hogstrom, Nobuhiro Ikei
Apr 14, 2006·Kidney International. Supplement·R SolomonUNKNOWN Consensus Panel for CIN
Oct 28, 2011·Revista española de cardiología·José Luis Górriz Teruel, Sandra Beltrán Catalán
Jun 15, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Louise MoistAndrew A House
Sep 12, 2009·Radiologic Clinics of North America·Richard W Katzberg, Ramit Lamba
Jul 7, 2007·Clinics in Podiatric Medicine and Surgery·Giovanni Ghirlanda, Lorena Mancini
Dec 19, 2007·Journal of Interventional Cardiology·Antonio L Bartorelli, Giancarlo Marenzi
Aug 10, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lingzhi HuSamuel A Wickline
May 15, 2010·Journal of Interventional Cardiology·Alessandro Mautone, Jeremiah R Brown
Dec 11, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·David M KayeStephen J Duffy
Feb 13, 2007·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Stewart R WalshJonathan R Boyle
Sep 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Naoko KamiyamaHisahiro Yoshida
Jul 9, 2008·The International Journal of Artificial Organs·D N CruzC Ronco
Oct 22, 2020·Journal of Translational Medicine·Prit KusirisinNipon Chattipakorn

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