Contrast material administration protocols for 64-MDCT angiography: altering volume and rate and use of a saline chaser to better match the imaging window--physiologic phantom study

AJR. American Journal of Roentgenology
Courtney A CourseyDavid M DeLong

Abstract

The purpose of our study was to evaluate the effect of varying volumes and rates of contrast material, use of a saline chaser, and cardiac output on aortic enhancement characteristics in MDCT angiography (MDCTA) using a physiologic phantom. Volumes of 75, 100, and 125 mL of iopamidol, 370 mg I/mL, were administered at rates of 4, 6, and 8 mL/s. The effect of a saline chaser (50 mL of normal saline, 8 mL/s) was evaluated for each volume and rate combination. Normal, reduced (33% and 50%), and increased (25%) cardiac outputs were simulated. Peak aortic enhancement and duration of peak aortic enhancement were recorded. Analysis of variance models were run with these effects, and the estimated mean levels for the sets of factor combinations were determined. Lowering the volume of contrast material resulted in reduced peak enhancement (example, -56.2 HU [p < 0.0001] with 75 vs 125 mL) and reduced duration of 75% peak enhancement (example, -9.0 seconds [p < 0.0001] with 75 vs 125 mL). Increasing the rate resulted in increased peak enhancement (example, 104.5 HU [p < 0.0001] with a rate of 8 vs 4 mL/s) and decreased duration of 75% peak enhancement (example, -13.0 seconds [p < 0.001]). Use of a saline chaser resulted in increased peak...Continue Reading

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Citations

Dec 24, 2010·AJR. American Journal of Roentgenology·Sebastian FeuerleinElmar M Merkle
Sep 8, 2011·The International Journal of Cardiovascular Imaging·Mustafa R BashirRendon C Nelson
Sep 11, 2010·Contrast Media & Molecular Imaging
Oct 2, 2019·AJR. American Journal of Roentgenology·David Y JohnsonDaniele Marin
Aug 1, 2019·Journal of Veterinary Science·Hyejin KimMincheol Choi

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