Contrast media as extracellular fluid space markers: adaptation of the central volume theorem

The British Journal of Radiology
P Dawson, Martin Blomley

Abstract

We present some theoretical observations on the pharmacokinetics of the conventional intravascular radiographic and gadolinium chelate MR contrast agents. These agents may be viewed from a physiological perspective as extracellular fluid (ECF) space markers. It can be shown that the passage of such agents through the body may be described by a variant of the "central volume theorem", if the central volume is taken to be that of the entire extracellular fluid. A consequence is that, in a manner akin to nuclear medicine techniques utilizing technetium-99m diethylene triamine pentacetic acid (DTPA), measures of glomerular filtration rate (GFR) related to total ECF volume rather than to the normal body surface area may be obtained from direct or indirect measurements of iodine or gadolinium plasma levels. Typical measurements are presented. A simple means is also described of generating curves of the fraction of contrast medium excreted from the body, applicable to both patients with normal and with abnormal renal function.

References

May 1, 1977·Acta Radiologica: Diagnosis·P B Dean, M Kormano
Jan 1, 1992·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A M Peters
May 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·S E BäckP Nilsson-Ehle
Nov 1, 1985·Investigative Radiology·L I JensenK Golman
Aug 1, 1996·Academic Radiology·P Dawson, M J Blomley
Aug 1, 1996·Academic Radiology·M J Blomley, P Dawson
Jun 1, 1954·Journal of Applied Physiology·P MEIER, K L ZIERLER
Nov 20, 1897·The Journal of Physiology·G N Stewart

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Citations

Jul 9, 2010·Radiologic Clinics of North America·Dominik Fleischmann
Feb 7, 2009·Radiologic Clinics of North America·Dominik Fleischmann, Aya Kamaya
Sep 19, 2006·European Journal of Radiology·Peter Dawson
Apr 30, 1998·Academic Radiology·P Dawson
Aug 23, 2002·Seminars in Dialysis·Peter Dawson
Mar 24, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Isabelle Goy-ThollotPaul Y Barthez

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