Contrast media: the relation of chemical structure, animal toxicity and adverse clinical effects

The American Journal of Cardiology
T Almén

Abstract

Chemotoxicity and osmotoxicity of contrast media (CM) are determined by chemical structure. The lower the chemotoxicity and osmotoxicity of the CM, the less animal toxicity and higher clinical tolerance in humans will be achieved. Nonionic monomers such as iohexol and iopamidol in iodine-equivalent concentrations have approximately half the osmolality and therefore half the osmotoxicity of ionic monomers such as diatrizoate, iodamide, iothalamate and metrizoate. Absence of carboxyl groups in nonionic CM, as opposed to the presence of carboxyl groups in ionic CM, results in a lower chemotoxicity in nonionic CM. Similarly, a larger number of hydroxyl groups in nonionic CM than in ionic CM result in a lower chemotoxicity. The lower chemotoxicity of nonionic CM is reflected as a higher subarachnoid and intravenous tolerance both in animals and in the clinical setting.

References

Jan 1, 1977·Acta Radiologica: Diagnosis·T AlménS E Lindell
Jan 1, 1985·Investigative Radiology·T Almén
Jan 1, 1985·Investigative Radiology·J T Lamb
Jan 1, 1973·Acta Radiologica. Supplementum·S Salvesen
May 1, 1984·AJR. American Journal of Roentgenology·T O GabrielsenJ T Hoff
Nov 1, 1984·Investigative Radiology·S Holtås

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Citations

Jan 1, 1995·European Journal of Radiology·S D OldroydS K Morcos
Aug 21, 2002·Academic Radiology·Hilde Kanli GaltungHaakon B Benestad
Dec 21, 2007·AJR. American Journal of Roentgenology·Yoshiki AsayamaHiroshi Honda
Feb 15, 2013·The Spine Journal : Official Journal of the North American Spine Society·Kyung-Hyun KimYong-Eun Cho
Jan 31, 2015·The Spine Journal : Official Journal of the North American Spine Society·Kyung-Hyun KimYong-Eun Cho
Jun 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Haitham Abu ShararEvangelos Giannitsis
Oct 6, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Scott D Fitzgerald, W Emmett Braselton
Apr 12, 2006·Circulation·Martin TepelNorbert Lameire
Nov 28, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Enrique EsplugasFrancisco Jara
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·V SanchezJ N Bruneton
Jan 1, 1995·Acta Radiologica. Supplementum·P JyngeA N Oksendal
Mar 23, 2017·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Samuel D KeyesAlan Marchant
Jul 26, 2018·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Caroline R EiversTobias Schwarz

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