Contrast sensitivity and optical quality of the eye after instillation of timolol maleate gel-forming solution and brinzolamide ophthalmic suspension

Ophthalmology
Takahiro HiraokaTetsuro Oshika

Abstract

To investigate the influence of timolol maleate 0.5% gel-forming solution and brinzolamide 1% ophthalmic suspension on contrast sensitivity, ocular higher-order aberration (HOA), and corneal surface light scattering. Prospective, comparative study. Forty normal volunteers were enrolled in this study. We evaluated contrast sensitivity, ocular HOA, and corneal light scattering before and 2, 5, 10, and 15 minutes after instillation of antiglaucoma eyedrops. Contrast sensitivity function was assessed with the CSV-1000RN chart (Vector Vision Co., Greenville, OH). Higher-order aberration was measured for a 4-mm pupil using the Hartmann-Shack aberrometer (KR-9000PW; Topcon, Tokyo, Japan). Corneal surface light scattering was quantitatively evaluated by using the Scheimpflug camera (EAS-1000, Nidek, Aichi, Japan). Time course of changes in contrast sensitivity, ocular HOAs, and corneal light scattering. Both timolol gel-forming solution and brinzolamide significantly decreased contrast sensitivity for at least 5 minutes after instillation (P<0.01). There were no significant differences in contrast sensitivity between the drugs at any time points. Higher-order aberration, such as third- and fourth-order aberrations and total HOAs, signi...Continue Reading

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Citations

Feb 11, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Minako KaidoKazuo Tsubota
Feb 18, 2016·Asia-Pacific Journal of Ophthalmology·Anjum CheemaKuldev Singh
Oct 19, 2012·Expert Opinion on Drug Delivery· AjazuddinShailendra Saraf
Jul 9, 2013·American Journal of Ophthalmology·Fumiki OkamotoTetsuro Oshika
Jan 20, 2016·Eye & Contact Lens·Shizuka KohNaoyuki Maeda
Jun 17, 2018·The British Journal of Ophthalmology·Shizuka KohVishal Jhanji
Aug 7, 2017·Internal Medicine Journal·Shizuka KohKohji Nishida
Aug 30, 2020·Journal of Clinical Medicine·Sujin HoshiTetsuro Oshika
Nov 15, 2016·Journal of Cataract and Refractive Surgery·Yoshihiko NinomiyaTetsuro Oshika

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