Contrast sensitivity, first-order motion and Initial ocular following in demyelinating optic neuropathy.

Journal of Neurology
Janet C RuckerR John Leigh

Abstract

The ocular following response (OFR) is a measure of motion vision elicited at ultra-short latencies by sudden movement of a large visual stimulus. We compared the OFR to vertical sinusoidal gratings (spatial frequency 0.153 cycles/ degrees or 0.458 cycles/ degrees) of each eye in a subject with evidence of left optic nerve demyelination due to multiple sclerosis (MS). The subject showed substantial differences in vision measured with stationary low-contrast Sloan letters (20/63 OD and 20/200 OS at 2.5% contrast) and the Lanthony Desaturated 15-hue color test (Color Confusion Index 1.11 OD and 2.14 OS). Compared with controls, all of the subject's OFR to increasing contrast showed a higher threshold. The OFR of each of the subject's eyes were similar for the 0.153 cycles/ degrees stimulus, and psychophysical measurements of his ability to detect these moving gratings were also similar for each eye. However, with the 0.458 cycles/ degrees stimulus, the subject's OFR was asymmetric and the affected eye showed decreased responses (smaller slope constant as estimated by the Naka-Rushton equation). These results suggest that, in this case, optic neuritis caused a selective deficit that affected parvocellular pathways mediating higher...Continue Reading

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Citations

May 22, 2009·Journal of Neurophysiology·Anand C JoshiR John Leigh
Apr 9, 2010·The International Journal of Neuroscience·Marco MandalàDaniele Nuti
Jun 6, 2009·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Ajoy VincentBhujang K Shetty
Apr 22, 2015·Journal of Optometry·Manuel Rodríguez-VallejoWalter D Furlan
Aug 29, 2012·Annals of Neurology·Kurt-Wolfram SühsRicarda Diem
Dec 1, 2007·International Ophthalmology Clinics·Janet C Rucker
Jun 18, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·S V KotovO M Anriukhina

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