Contrast settling in cerebral aneurysm angiography

Physics in Medicine and Biology
Zhi-Jie WangHui Meng


During angiography, blood flow is visualized with a radiopaque contrast agent, which is denser than blood. In complex vasculature, such as cerebral saccular aneurysms, the density difference may produce an appreciable gravity effect, where the contrast material separates from blood and settles along the gravity direction. Although contrast settling has been occasionally reported before, the fluid mechanics behind it have not been explored. Furthermore, the severity of contrast settling in cerebral aneurysms varies significantly from case to case. Therefore, a better understanding of the physical principles behind this phenomenon is needed to evaluate contrast settling in clinical angiography. In this study, flow in two identical groups of sidewall aneurysm models with varying parent-vessel curvature was examined by angiography. Intravascular stents were deployed into one group of the models. To detect contrast settling, we used lateral view angiography. Time-intensity curves were analysed from the angiographic data, and a computational fluid dynamic analysis was conducted. Results showed that contrast settling was strongly related to the local flow dynamics. We used the Froude number, a ratio of flow inertia to gravity force, t...Continue Reading


Jan 1, 1984·Biorheology·H NiimiI Sugiyama
Feb 1, 1995·The British Journal of Radiology·D S Tarver, G R Plant
May 1, 1997·Annals of Biomedical Engineering·Baruch B LieberA K Wakhloo
Mar 1, 1997·Medical Engineering & Physics·E T LeeE G Cape
Aug 8, 1998·Neurosurgery·A K WakhlooL Nelson Hopkins
May 8, 1999·Physics in Medicine and Biology·R S Lawson
Sep 22, 2000·Critical Reviews in Biomedical Engineering·R M RobinsonK E Forsten
Jun 21, 2002·Neurological Research·Baruch B Lieber, Matthew J Gounis
Jan 1, 2004·Proceedings - Society of Photo-Optical Instrumentation Engineers·Ciprian IonitaStephen Rudin
Apr 1, 2004·Proceedings - Society of Photo-Optical Instrumentation Engineers·Zhou WangDaniel R Bednarek


Apr 26, 2008·Stroke; a Journal of Cerebral Circulation·Ciprian IonitaJ Duffy Mocco
Jan 10, 2009·Stroke; a Journal of Cerebral Circulation·Ciprian IonitaJ Duffy Mocco
Dec 10, 2009·Medical Physics·Baruch B LieberLiliana Cesar
Dec 15, 2005·IEEE Transactions on Medical Imaging·Matthew D FordD A Steinman
Nov 30, 2012·Computational and Mathematical Methods in Medicine·Jürgen EndresArnd Dörfler
Aug 20, 2020·Journal of the Royal Society, Interface·Mark Epshtein, Netanel Korin

Related Concepts

Blood Flow Velocity
Mycotic Aneurysm, Intracranial
Cerebral Angiography
In Silico
Radiographic contrast media
Digital Radiography
Radiographic Image Interpretation, Computer-Assisted
Morphologic Artifacts
Radiologic Phantoms

Related Feeds


Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.