Contrasted impact of maternal rat food restriction on the fetal endocrine pancreas

Endocrinology
C AlvarezA M Pascual-Leone

Abstract

The effects of food restriction of the mother (65% restriction of ad libitum food intake) on fetal and maternal insulin secretion and islet function were studied at 21 days gestation in three different rat populations: 1) undernourished from 0-7 days gestation, 2) undernourished from 7-14 days gestation, and 3) undernourished from 14-21 days gestation. The body weights of mothers were decreased in groups 2 and 3 vs. those in control fed pregnant animals, and no changes in basal parameters were found in any group. A glucose tolerance test in mothers from group 3 showed a mild intolerance to glucose and a decreased islet insulin content, although islet stimulation in vitro with glucose alone or plus arginine showed a normal insulin secretory response. Body weight was decreased in fetuses from the three groups (P < 0.01), and pancreas weight was reduced only in group 3. Insulinemia was increased in groups 2 and 3, and pancreatic insulin content increased only in group 3. However, fetuses from mothers of group 3 showed increased islet insulin content, increased response of insulin in vitro to glucose or glucose plus arginine, and hypertrophy of beta-cell mass. These results indicate, first, that the development of the fetal pancrea...Continue Reading

References

May 1, 1977·The Journal of Endocrinology·L Aerts, F A van Assche
Mar 1, 1985·Molecular and Cellular Endocrinology·J L MourmeauxJ C Henquin
Jul 1, 1972·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E Heinze, J Steinke
May 1, 1971·The Journal of Clinical Investigation·N V Costrini, R K Kalkhoff
Dec 1, 1971·Endocrinology·S Sybulski, G B Maughan
Jun 1, 1984·Metabolism: Clinical and Experimental·M B Davidson
Jan 1, 1982·Biology of the Neonate·U Eriksson, I Swenne
Jul 1, 1983·Metabolism: Clinical and Experimental·C M BrownscheidleI A Hofmann
Jan 1, 1980·Diabetologia·A LeturqueJ Girard
Nov 14, 1939·The Journal of Physiology·C H BestJ H Ridout

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Citations

Oct 14, 2008·Early Human Development·Kathryn Beardsall, David Dunger
Jan 24, 2009·Annals of the New York Academy of Sciences·Aldo RozzoMarjan Rupnik
Nov 6, 2008·Acta Physiologica·M Rupnik
Oct 26, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert G Ellis-HutchingsJohn M Rogers
Apr 15, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Sandra Lúcia SchulerLúcia de Noronha
Dec 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·M A MartínC Alvarez
Jun 8, 2006·American Journal of Physiology. Endocrinology and Metabolism·E FernándezC Alvarez
May 6, 2011·The American Journal of Clinical Nutrition·Jane L Tarry-Adkins, Susan E Ozanne
Nov 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Patrícia R GomesSilvana Bordin
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric BertinBernard Portha
Aug 17, 2006·American Journal of Physiology. Endocrinology and Metabolism·Elisa FernándezCarmen Alvarez
Jul 28, 2020·Biomolecules·Blandine GausserèsKamel Maouche
Oct 21, 2020·Scientific Reports·Juan de Toro-MartínElisa Fernández-Millán
Aug 10, 2021·Frontiers in Pediatrics·Kathryn Beardsall

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