PMID: 6407295Jun 1, 1983Paper

Contrasting acute effects of vasodilators (nitroglycerin, nitroprusside, and hydralazine) on right ventricular performance in patients with chronic obstructive pulmonary disease and pulmonary hypertension: a combined radionuclide-hemodynamic study

The American Journal of Cardiology
B N BrentB L Zaret

Abstract

Fourteen patients with chronic obstructive pulmonary disease, mild to moderate pulmonary hypertension, and diminished right ventricular (RV) ejection fraction were studied acutely with use of a combined radionuclide-hemodynamic approach to assess and contrast the effects of 3 vasodilators on RV performance and central hemodynamic function. Nitroglycerin significantly decreased mean right atrial pressure, RV end-diastolic volume index, mean pulmonary artery pressure, cardiac index, and arterial oxygen tension, but did not affect pulmonary vascular resistance index and increased RV ejection fraction. Nitroprusside had similar effects on mean right atrial pressure, RV end-diastolic volume index, mean pulmonary artery pressure, cardiac index, and arterial oxygen tension, but also mildly decreased pulmonary vascular resistance index and did not alter RV ejection fraction. In contrast, hydralazine decreased pulmonary vascular resistance index and increased cardiac index and RV ejection fraction. The increase in ejection fraction correlated well with the decrease in pulmonary vascular resistance. These data suggest that in patients with mild to moderate secondary pulmonary hypertension, acute administration of hydralazine results in a...Continue Reading

References

Jan 1, 1977·Progress in Cardiovascular Diseases·K Chatterjee, W W Parmley
May 1, 1979·Annals of Internal Medicine·J N Ruskin, A M Hutter
Nov 1, 1979·Annals of Internal Medicine·J N Cohn, L P Burke
Nov 1, 1978·The American Journal of Cardiology·F S DaoudD B Kelly
Aug 5, 1976·The New England Journal of Medicine·J Koch-Weser
May 29, 1980·The New England Journal of Medicine·J Abrams
Jun 3, 1982·The New England Journal of Medicine·M PackerH Dash
Oct 1, 1982·Annals of Internal Medicine·J B HermillerC V Leier
Jun 25, 1981·The New England Journal of Medicine·G SimonneauA Lockhart
Nov 1, 1981·Annals of Internal Medicine·M L Cohen, I Kronzon
Jan 10, 1980·The New England Journal of Medicine·L J Rubin, R H Peter
Jan 10, 1980·The New England Journal of Medicine·W P Klinke, J A Gilbert
Jan 1, 1981·The American Journal of Cardiology·L J Rubin, R H Peter

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Citations

Jan 1, 1987·Cardiovascular and Interventional Radiology·J GrégoireB L Holman
May 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B BourreliJ P Remi
Sep 1, 1986·Canadian Anaesthetists' Society Journal·F A BurrowsD J Bohn
May 10, 2005·The American Journal of Cardiology·Barry Lewis Zaret
Apr 1, 1984·Journal of the American College of Cardiology·B V MannoA H Hakki
Jan 14, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN American College of Chest Physicians
Oct 1, 1991·Current Problems in Cardiology·L J Dell'Italia
Jun 27, 2002·Expert Opinion on Investigational Drugs·Chen-Fuh LamPeter V van Heerden
Jul 1, 1988·The American Journal of the Medical Sciences·C K ChanR A Matthay
Aug 14, 2018·Expert Review of Cardiovascular Therapy·J Alberto NederDenis E O'Donnell
Mar 7, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Chih-Tai TingFrank C P Yin
Oct 1, 1989·Disease-a-month : DM·M L MurphyD Nicholson

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