Abstract
Hypertension is a common finding in non-insulin-dependent diabetes mellitus (NIDDM) nephropathy. African Americans have a high prevalence of NIDDM and hypertension, and are relatively resistant to the antihypertensive effects of converting enzyme inhibitors (CEI) but respond well to calcium channel blockers (CCB). In the long-term study presented here, the effects of isradipine, a dihydropyridine calcium antagonist, on the course of the nephropathy were investigated and compared with the effects of captopril in 31 African Americans with NIDDM and proteinuria (> or = 500 mg/day). The patients were stratified by levels of GFR and proteinuria, and they were randomized to receive isradipine (N = 16) or captopril (N = 15); doses were adjusted to maintain similar BP levels (< 140/90). At 6 months, mean arterial pressure was similar (102 +/- 3 and 104 +/- 3 mm Hg in the isradipine and captopril groups, respectively) and GFR was unchanged (delta = -4 +/- 3 and +1 +/- 3 ml/min/1.73 in the isradipine and captopril groups, respectively; P = NS). However, proteinuria in the isradipine group increased by approximately 50% (2.01 +/- 0.40 versus 3.04 +/- 0.70 mg/mg creatinine at baseline versus 6 months, respectively, P < 0.05), whereas capto...Continue Reading
Citations
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·W Kriz, K V Lemley
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B Nielsen, A Flyvbjerg
May 9, 2001·Current Opinion in Nephrology and Hypertension·K EndlichR Witzgall
Jun 11, 1999·Journal of the American Society of Nephrology : JASN·D J CordonnierR W Bilous
Feb 28, 2021·Kidney International·UNKNOWN Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group
Apr 11, 2000·The Journal of Maternal-fetal Medicine·D L Conway, O Longer
Jul 28, 2001·Acta medica Austriaca·A R Rosenkranz
May 7, 1999·Kidney International·C M Nzerue
Oct 8, 1999·The New England Journal of Medicine·E Ritz, S R Orth
Dec 24, 2002·Current Opinion in Nephrology and Hypertension·Nicholas Kaperonis, George Bakris
Nov 2, 2002·Kidney International. Supplement·Francesco LocatelliSara Colzani
Jul 3, 2003·Seminars in Nephrology·Anupama Mohanram, Robert D Toto
Sep 7, 2000·Journal of Clinical Pharmacology·E Basta, G L Bakris
Apr 27, 2005·Clinical Cornerstone·Domenic Sica
Oct 20, 2005·Pharmacotherapy·David B Hughes, Mark L Britton
Sep 12, 2000·Current Hypertension Reports·P S Mehler, R W Schrier
Sep 2, 2003·Current Hypertension Reports·Douglas A Nigbor, Julia B Lewis
Oct 16, 2004·Current Cardiology Reports·Mitra K NadimVito M Campese
Apr 17, 2008·Journal of Diabetes and Its Complications·Ali JawaVivian Fonseca