Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue-evoked goal-directed behavior

The European Journal of Neuroscience
Irene A YunH L Fields

Abstract

Discriminative stimuli (DSs) inform animals that reward can be obtained contingent on the performance of a specific behavior. Such stimuli reinstate drug-seeking behavior, evoke dopamine release in the nucleus accumbens (NAc) and excite and inhibit specific subpopulations of NAc neurons. Here we show in rats that DSs can reinstate food-seeking behavior. In addition, we compare the effects of injecting dopamine receptor antagonists into the NAc with those of general NAc inactivation on the performance of a DS task. Selective antagonism of D1 receptors reduced responding to the DS and increased the latency to respond, whereas general inactivation of NAc neuronal activity increased the latency to respond to the DS and increased behaviors extraneous to the task, such as responding in the absence of cues and responding on the inactive lever. Based on these results and our previous findings that NAc neuronal responses to DSs are dependent on the ventral tegmental area, we propose a model for the functional role of NAc neurons in controlling behavioral responses to reward-predictive stimuli.

References

Mar 1, 1979·Experimental Neurology·M K SangheraA Roper-Hall
Jan 1, 1992·Journal of Neurophysiology·T LjungbergW Schultz
Jul 1, 1990·Trends in Neurosciences·G E Alexander, M D Crutcher
Jul 1, 1990·Trends in Neurosciences·M R DeLong
Dec 13, 1991·Behavioural Brain Research·P J Reading, S B Dunnett
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R D Oades
Jan 1, 1981·Psychopharmacology·H de Wit, J Stewart
Dec 1, 1993·Current Opinion in Neurobiology·J W Mink, W T Thach
Mar 1, 1996·Neuroscience·M F MontaronA M Thierry
Jan 1, 1997·Critical Reviews in Neurobiology·P WinnW L Inglis
Aug 6, 1998·Neuroscience·D R SmithM Gallagher
Aug 15, 1998·Journal of Neurophysiology·J R HollermanW Schultz
Nov 5, 1998·Pharmacology, Biochemistry, and Behavior·J E AbermanJ D Salamone
Dec 31, 1998·Experimental Brain Research·E M Bowman, V J Brown
Jun 11, 1999·Neuroscience·P RedgraveK Gurney

❮ Previous
Next ❯

Citations

Sep 20, 2006·Psychopharmacology·Saleem M Nicola
Oct 27, 2004·Cell and Tissue Research·Saleem M NicolaGregory O Hjelmstad
Dec 17, 2009·Behavioral Neuroscience·Won Yung ChoiJon C Horvitz
Dec 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lily Alvarez-JaimesLoren H Parsons
Dec 8, 2009·Biological Reviews of the Cambridge Philosophical Society·Newton Ressler
Mar 23, 2007·Annual Review of Neuroscience·Howard L FieldsSaleem M Nicola
May 9, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akinori IshikawaHoward L Fields
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael W ShiflettEdda Thiels
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexis FaureKent C Berridge
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Frederic AmbroggiHoward L Fields
Feb 10, 2010·Behavioral Neuroscience·Tiffany Galtress, Kimberly Kirkpatrick
Feb 8, 2011·Pharmacology, Biochemistry, and Behavior·Bríd Áine Nic Dhonnchadha, Kathleen M Kantak
Nov 26, 2009·Neurobiology of Learning and Memory·Bjoern Lex, Wolfgang Hauber
Jul 15, 2009·Journal of Chemical Neuroanatomy·Samuel D Gale, David J Perkel
Nov 6, 2008·Behavioural Brain Research·Margaret R ZellnerRobert Ranaldi
Aug 5, 2008·Neuropharmacology·William A Carlezon, Mark J Thomas
Oct 4, 2005·The European Journal of Neuroscience·Amy ZmarowskiJohn P Bruno
Dec 3, 2008·The European Journal of Neuroscience·Nadia ChaudhriPatricia H Janak
Nov 18, 2005·European Journal of Pharmacology·Jennifer M BossertYavin Shaham
Jan 2, 2006·Cognitive Science·Thomas T Hills
Dec 6, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xuan LiYavin Shaham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.