PMID: 2112072Jan 1, 1990Paper

Contrasting effects of norepinephrine and 5-hydroxytryptamine on contractility of abdominal aorta of two kidney-two clip hypertensive rats. Effects of inhibitors of arachidonic acid metabolic enzymes

Clinical and Experimental Hypertension. Part A, Theory and Practice
M I RosónI J de la Riva

Abstract

This study intends to: 1) define reactivity in vessels of two kidney-two clip (2K2C) hypertensive rats (6-11 days after clipping); 2) determine the possible involvement of prostaglandins in modulating contractile vascular responses. Cumulative dose-response curves to norepinephrine (NE), 5-hydroxytryptamine (5-HT) and potassium chloride (KCl) were elicited on helical strips of abdominal aorta both in the absence and in the presence of prostacyclin synthetase (transylcypromine, TCP, 0.25mM) or cyclooxygenase (indomethacin, IND, 0.014 mM and acetylsalicylic acid, ASA, 0.20 mM) inhibitors Vessels of hypertensive animals developed significantly less tension to NE (n = 21) but higher tension and lower ED50 in response to 5-HT (n = 9) than sham control rat vessels. Force development to KCl (n = 9) was not statistically different between hypertensive and sham vessels. Vascular responses were decreased with the inhibitors, but the contrasting effects of NE and 5-HT on clip vessels were maintained. Threshold doses of PGE2 significantly reversed the effect of IND but not that of TCP on NE responses. Threshold doses of PGI2 had no significant effect on NE and 5-HT responses under TCP. The results would indicate: 1) different functional al...Continue Reading

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Citations

Mar 13, 2012·Pharmacological Reviews·Stephanie W WattsSusan M Barman
Jul 1, 1995·Clinical and Experimental Hypertension : CHE·G W VegaI J de la Riva
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·M Peral de BrunoW G Forssmann
Jan 1, 1994·Clinical and Experimental Hypertension : CHE·D B StrattonB J Sanders
May 4, 2010·Cardiovascular Therapeutics·Stephanie W Watts, Robert Patrick Davis
Jul 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Kevin OgdenStephanie W Watts
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Amber RussellStephanie W Watts
Apr 16, 2005·Clinical Science·Stephanie W Watts

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