Contrasting effects of vitamins as modulators of apoptosis in cancer cells and normal cells: a review

Nutrition and Cancer
William C Cole, Kedar N Prasad

Abstract

Individual vitamins can induce direct apoptosis or indirect apoptosis via cell differentiation in cancer cells; however, they can also stimulate antiapoptotic events in certain cancer cells. These effects depend on the dose, type, and form of vitamins and the type of tumor cells. A mixture of antioxidant vitamins is more effective than individual vitamins, and there is no evidence that such a mixture ever stimulates antiapoptotic events in cancer cells. Vitamins in combination with nonvitamin, direct-acting, apoptotic agents (X-rays, chemotherapeutic agents, and hyperthermia) or in combination with nonvitamin, indirect-acting, apoptotic agents (adenosine 3',5'-cyclic monophosphate, butyric acid, and interferon) produce a greater extent of apoptotic death in cancer cells in culture. Certain antioxidant vitamins may reduce the efficacy of some chemotherapeutic agents on rodent fibrosarcoma cells. In contrast to vitamin-induced apoptosis in cancer cells, normal cells never undergo apoptotic death after treatment with vitamins (not including retinoids). On the contrary, vitamins protect normal cells against apoptosis induced by a certain group of chemicals. The reasons for this differential effect of vitamins on cancer and normal c...Continue Reading

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