Contrasting influences of age and sex on muscle fatigue

Medicine and Science in Sports and Exercise
David W RussJ Kent-Braun

Abstract

Greater resistance to muscle fatigue has been observed in women versus men and in older versus young individuals. As suggested mechanisms for these differences include task intensity and duty cycle, the purpose of this study was to evaluate fatigue in healthy young and older men and women during maximum-effort isometric contractions with a 70% duty cycle (7 s of contraction, 3 s of rest). We hypothesized that no differences in fatigue would be observed across age or sex, in contrast to studies incorporating lower duty cycles. The protocol was carried out on ankle dorsiflexors of older (73 +/- 1 yr) and younger (25 +/- 1 yr) men and women. Volitional and stimulated force, compound muscle action potential, and muscle contractile responses were collected before, during, and immediately after the fatigue protocol. These measurements allowed for assessment of fatigue as well as central and peripheral activation. At baseline, older subjects had longer force half-relaxation times and less twitch potentiation than younger subjects, consistent with a slower muscle phenotype. During contractions, younger subjects fatigued more than older subjects did, with no differences between men and women. Central activation decreased similarly in al...Continue Reading

References

Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·C M CupidoJ Martin
May 1, 1992·Journal of Applied Physiology·R M Enoka, D G Stuart
Dec 1, 1988·Muscle & Nerve·F JakobssonL Grimby
Jan 1, 1986·European Journal of Applied Physiology and Occupational Physiology·R J MaughanA Delman
Jan 1, 1985·American Journal of Epidemiology·J F SallisR S Paffenbarger
Jan 1, 1985·Canadian Journal of Physiology and Pharmacology·J A SimoneauC Bouchard
Jan 1, 1994·Physiological Reviews·R H Fitts
Sep 1, 1996·Pflügers Archiv : European journal of physiology·S D HarridgeB Saltin
Jan 1, 1996·Medicine and Science in Sports and Exercise·M G BembenR A Boileau
Dec 1, 1996·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·A L Hicks, N McCartney
Jan 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·B LindströmD Downham
Jun 6, 1998·Journal of Applied Physiology·M HargreavesM A Febbraio
Apr 8, 1999·Journal of Applied Physiology·S A Binder-Macleod, D W Russ
Aug 13, 1999·Journal of Applied Physiology·D M ConnellyA A Vandervoort
Jun 14, 2000·Journal of Applied Physiology·T HamadaM A Tarnopolsky
Nov 15, 2000·Canadian Journal of Physiology and Pharmacology·D S Ditor, A L Hicks
Jan 11, 2001·Muscle & Nerve·M BilodeauJ B Weeks
Jul 7, 2001·Archives of Physical Medicine and Rehabilitation·J E StevensL Snyder-Mackler
Jul 13, 2002·Muscle & Nerve·Brian L Allman, Charles L Rice
Jul 23, 2002·Journal of Applied Physiology·David W RussStuart A Binder-Macleod
Feb 4, 2003·Journal of Applied Physiology·David W Russ, Jane A Kent-Braun
Sep 2, 2003·Journal of Applied Physiology·Anna Maria HolmbäckJan Lexell
Nov 5, 2003·Journal of Applied Physiology·Brian L Allman, Charles L Rice
May 18, 2004·Journal of Applied Physiology·Ian R LanzaJane A Kent-Braun
Mar 26, 2005·European Journal of Applied Physiology·Brian C ClarkLori L Ploutz-Snyder
Jul 9, 2005·Journal of Applied Physiology·Ian R LanzaJane A Kent-Braun
Jul 19, 2005·Muscle & Nerve·David W RussJane A Kent-Braun
Nov 8, 2005·Experimental Brain Research·Kevin G KeenanRoger M Enoka
May 27, 2006·Journal of Applied Physiology·Sandra K HunterJanet L Taylor

❮ Previous
Next ❯

Citations

Oct 25, 2013·Medicine and Science in Sports and Exercise·Abbie E Smith-RyanJeffrey R Stout
Dec 23, 2008·Exercise and Sport Sciences Reviews·Jane A Kent-Braun
Jun 25, 2009·Exercise and Sport Sciences Reviews·Sandra K Hunter
Oct 1, 2010·Medicine and Science in Sports and Exercise·Anita ChristieJane A Kent-Braun
Oct 26, 2010·European Journal of Applied Physiology·Gary R HunterBradley R Newcomer
May 28, 2011·Physical Therapy·Keith G Avin, Laura A Frey Law
May 1, 2009·European Journal of Applied Physiology·Konstantina DiplaSpyros Kellis
Oct 7, 2015·Experimental Physiology·Sandra K Hunter
Apr 6, 2012·Journal of Cachexia, Sarcopenia and Muscle·David W RussBrian C Clark
Aug 21, 2010·Journal of the American Geriatrics Society·Neil B AlexanderStephanie Studenski
Nov 17, 2009·Research in Developmental Disabilities·Andreas ZafeiridisEleftherios Kellis
Feb 22, 2012·Journal of Strength and Conditioning Research·Brad J Schoenfeld
Apr 25, 2018·The Journal of Sports Medicine and Physical Fitness·José C Jambassi-FilhoSebastião Gobbi
Sep 19, 2019·The Journal of Physiology·Paul AnsdellStuart Goodall
Nov 7, 2019·Medicine and Science in Sports and Exercise·Vianney RozandAshleigh E Smith
Aug 8, 2009·Journal of Strength and Conditioning Research·Eric S Rawson
Nov 7, 2019·Medicine and Science in Sports and Exercise·Haley V GabelGeoffrey A Power
Jan 1, 2012·Preventing School Failure : Alternative Education for Children and Youth·Hyunjeong ChoNeil Kingston
Sep 24, 2020·The Journal of Physiology·Paul AnsdellStuart Goodall
Dec 24, 2018·Aging and Disease·Vinicius Alota Ignacio PereiraLilian Teresa Bucken Gobbi
Mar 4, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sharn ShelleyJason Tallis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.