Contrasting levels of DNA polymorphism at the autosomal and X-linked visual color pigment loci in humans and squirrel monkeys

Molecular Biology and Evolution
L C ShimminW H Li

Abstract

The X-linked color pigment (opsin) locus is known to be highly polymorphic in the squirrel monkey and other New World monkeys. To see whether this is also the case for the autosomal (blue) opsin locus, we obtained 32 squirrel monkey and 30 human blue opsin gene sequences. No amino acid polymorphism was found in either the squirrel monkey sample or the human sample, contrary to the situation at the X-linked opsin locus. This sharp contrast in the level of polymorphism might be due to differences in gene expression between the autosomal and the X-linked loci. At the X-linked locus, heterozygote advantage can occur because, owing to X-inactivation, the two alleles in a heterozygote are expressed in different cone cells, producing two types of cone cell, whereas at the autosomal locus, heterozygote advantage cannot occur because the two alleles in a heterozygote are expressed in the same cone cells, producing only one type of cone cell (i.e., phenotypically a homozygote). From the sequence data, the levels of nucleotide diversity (pi, i.e., the number of nucleotide differences per site) are estimated: for the human sample, pi = 0.00% per nondegenerate site, 0.00% per twofold degenerate site, and 0.04% per fourfold degenerate site i...Continue Reading

Citations

Oct 29, 2009·Molecular Biology and Evolution·Tomohide HiwatashiShoji Kawamura
Jan 8, 2016·Molecular Biology and Evolution·Amanda D MelinNathaniel J Dominy
Dec 13, 2005·American Journal of Primatology·Chihiro HiramatsuShoji Kawamura
Jan 27, 2019·Science·Bjarni V HalldorssonKari Stefansson
Nov 8, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Josep M Comeron
Oct 8, 2004·Annals of Human Genetics·S Alonso, J A L Armour
Sep 5, 2008·PLoS Genetics·Scott W DonigerJustin C Fay
Oct 19, 2006·PLoS Genetics·Chris C A SpencerGil McVean
Apr 11, 2015·PLoS Biology·Russell B Corbett-DetigTimothy B Sackton
Jun 9, 2009·PLoS Genetics·Guy SellaPeter Andolfatto
Dec 28, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael W Nachman, Bret A Payseur
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wolfgang Stephan
Sep 30, 2020·American Journal of Primatology·Viviani MantovaniDaniela M O Bonci

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