Contrasting modes of natural selection acting on pigmentation genes in the Drosophila dunni subgroup

Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
J A WilderHope Hollocher

Abstract

Genes that encode for divergent adaptive traits may have genealogies that contrast with those from loci that are not functionally involved in differentiation. Here, we examine DNA sequence variation among the species of the eastern Caribbean Drosophila dunni subgroup at two loci, yellow and dopa decaboxylase (Ddc), which both play integral roles in pigmentation patterning of adult Drosophila. Phylogenetic analyses of these loci produce gene genealogies with topologies that mirror those described for other nuclear genes: the six morphologically distinct species within the subgroup are divided into only three lineages, with one lineage containing four species that share extensive ancestral polymorphism. At the Ddc locus these major lineages are delineated only by silent site variation. We observe a significantly higher rate of synonymous site divergence than non-synonymous divergence, consistent with strong purifying selection acting on the locus. In contrast, the yellow locus exhibits patterns of amino acid divergence and nucleotide diversity that are consistent with recent diversifying selection acting in two different lineages. This selection appears to be targeting amino acid variants in the signal sequence of the Yellow prot...Continue Reading

References

Apr 1, 1975·Theoretical Population Biology·G A Watterson
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M SakaguchiT Omura
Jun 20, 1991·Nature·J H McDonald, M Kreitman
May 1, 1990·The Journal of Membrane Biology·G von Heijne
May 1, 1987·Genetics·R R HudsonM Aguadé
Jan 15, 1974·Biochemistry·P Y Chou, G D Fasman
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B L TempelW G Quinn
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·M W NachmanC F Aquadro
Sep 1, 1993·Genetics·G B GloorW R Engels
Jun 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Hollocher
Nov 12, 1998·Trends in Biochemical Sciences·F JeanmouginT J Gibson
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·C T TingC I Wu
Jul 6, 2000·Genetics·J C Fay, C I Wu
Feb 24, 2001·Evolution; International Journal of Organic Evolution·H HollocherE G Dyreson
Feb 24, 2001·Evolution; International Journal of Organic Evolution·H HollocherE G Dyreson
Dec 26, 2001·Bioinformatics·S KumarM Nei
Mar 20, 2002·Genetics·Molly Przeworski
Oct 10, 2002·Current Biology : CB·Patricia J WittkoppSean B Carroll
Dec 19, 2002·Evolution; International Journal of Organic Evolution·Ana LlopartJerry A Coyne
Feb 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Patricia J WittkoppSean B Carroll
Apr 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael W NachmanSusan L D'Agostino
May 29, 2003·The Journal of Biological Chemistry·D Thomas RutkowskiVishwanath R Lingappa
Sep 2, 2003·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Sep 6, 2003·Trends in Genetics : TIG·Patricia J WittkoppArtyom Kopp

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Citations

Jul 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Leah S RonaldEvgeni V Sokurenko
Aug 9, 2006·Evolution; International Journal of Organic Evolution·Jennifer A BrissonHope Hollocher
Jul 31, 2013·Evolution; International Journal of Organic Evolution·Daniel R Matute, Alexandra Harris

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