Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes

PloS One
Parmveer Singh, David M Irwin

Abstract

ChREBP and MondoA are glucose-sensitive transcription factors that regulate aspects of energy metabolism. Here we performed a phylogenomic analysis of Mlxip (encoding MondoA) and Mlxipl (encoding ChREBP) genes across vertebrates. Analysis of extant Mlxip and Mlxipl genes suggests that the most recent common ancestor of these genes was composed of 17 coding exons. Single copy genes encoding both ChREBP and MondoA, along with their interacting partner Mlx, were found in diverse vertebrate genomes, including fish that have experienced a genome duplication. This observation suggests that a single Mlx gene has been retained to maintain coordinate regulation of ChREBP and MondoA. The ChREBP-β isoform, the more potent and constitutively active isoform, appeared with the evolution of tetrapods and is absent from the Mlxipl genes of fish. Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.

References

Dec 14, 1999·The Journal of Biological Chemistry·A N BillinD E Ayer
Apr 26, 2000·Genome Research·S SchwartzW Miller
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·H YamashitaK Uyeda
Jul 24, 2002·Nucleic Acids Research·Kazutaka KatohTakashi Miyata
Jun 26, 2003·Nucleic Acids Research·Scott SchwartzWebb Miller
Jun 3, 2004·Genome Research·Gavin E CrooksSteven E Brenner
Jan 25, 2005·The Journal of Biological Chemistry·Lin MaHoward C Towle
Aug 19, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Axel Meyer, Yves Van de Peer
May 24, 2007·Bioinformatics·John A Capra, Mona Singh
Jul 25, 2008·The Biochemical Journal·Loranne Agius
Aug 30, 2008·Cellular and Molecular Life Sciences : CMLS·P B Iynedjian
Oct 9, 2008·American Journal of Physiology. Endocrinology and Metabolism·David H Wasserman
Feb 20, 2009·Genome Biology·Jennifer HarrowRoderic Guigó
May 26, 2010·Nucleic Acids Research·Osnat PennTal Pupko
Aug 26, 2010·Journal of Receptor and Signal Transduction Research·Keiko Hirota, Akiyoshi Fukamizu
Aug 24, 2011·Genome Biology and Evolution·Lisa G McFerrin, William R Atchley
Oct 13, 2011·Molecular Systems Biology·Fabian SieversDesmond G Higgins
Feb 24, 2012·Systematic Biology·Fredrik RonquistJohn P Huelsenbeck
Mar 13, 2012·Seminars in Cell & Developmental Biology·Essi Havula, Ville Hietakangas
Apr 17, 2012·PloS One·Lisa G McFerrin, William R Atchley
Apr 19, 2012·Nature Reviews. Genetics·Mark Yandell, Daniel Ence
May 16, 2012·Advances in Nutrition·Mary Courtney MooreAlan D Cherrington
Feb 28, 2013·Nature Communications·Leah EissingLudger Scheja
Apr 23, 2013·Endocrine Journal·Katsumi Iizuka
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 8, 2013·Cellular and Molecular Life Sciences : CMLS·Maaike H Oosterveer, Kristina Schoonjans
Apr 3, 2014·Comprehensive Physiology·Liangyou Rui
Jun 5, 2014·Nutrition Research Reviews·Stéphane PanseratSergio Polakof
Sep 10, 2014·Diabetes, Obesity & Metabolism·J M Rojas, M W Schwartz
Nov 26, 2014·Diabetologia·Bernard Thorens

❮ Previous
Next ❯

Citations

Jul 6, 2019·Frontiers in Genetics·Paula Ortega-Prieto, Catherine Postic
Nov 21, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Luqing CuiZonghui Yuan

❮ Previous
Next ❯

Software Mentioned

ChREBP
BIONJ
Tracer
WebLogo
MAFFT
tblastn
MondoA
blastx
RepeatMasker
MultiPipMaker

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Cell & Developmental Biology
Essi Havula, Ville Hietakangas
Journal of Molecular Evolution
David M Irwin, Zhiyuan Gong
Nihon rinsho. Japanese journal of clinical medicine
Katsumi Iizuka
Journal of Molecular Evolution
J J Beintema
© 2022 Meta ULC. All rights reserved