Contrasting patterns of RUNX2 repeat variations are associated with palate shape in phyllostomid bats and New World primates

Scientific Reports
Tiago FerrazTábita Hünemeier

Abstract

Establishing the genetic basis that underlies craniofacial variability in natural populations is one of the main topics of evolutionary and developmental studies. One of the genes associated with mammal craniofacial variability is RUNX2, and in the present study we investigated the association between craniofacial length and width and RUNX2 across New World bats (Phyllostomidae) and primates (Catarrhini and Platyrrhini). Our results showed contrasting patterns of association between the glutamate/alanine ratios (Q/A ratio) and palate shape in these highly diverse groups. In phyllostomid bats, we found an association between shorter/broader faces and increase of the Q/A ratio. In New World monkeys (NWM) there was a positive correlation of increasing Q/A ratios to more elongated faces. Our findings reinforced the role of the Q/A ratio as a flexible genetic mechanism that would rapidly change the time of skull ossification throughout development. However, we propose a scenario in which the influence of this genetic adjustment system is indirect. The Q/A ratio would not lead to a specific phenotype, but throughout the history of a lineage, would act along with evolutionary constraints, as well as other genes, as a facilitator for a...Continue Reading

References

Oct 30, 1998·The Annals of Occupational Hygiene·J F FabrièsJ C Vigneron
Jul 1, 1986·Journal of the History of Biology·D J Futuyma
Feb 22, 2002·Human Mutation·Florian OttoStefan Mundlos
May 29, 2003·The Journal of Experimental Biology·Elizabeth R Dumont, Anthony Herrel
Jul 2, 2003·Molecular Biology and Evolution·Carlos G Schrago, Claudia A M Russo
Mar 18, 2004·The American Naturalist·Gabriel Marroig, James M Cheverud
May 25, 2004·Oncogene·Ditsa Levanon, Yoram Groner
Sep 9, 2004·Science·Arhat AbzhanovClifford J Tabin
Dec 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·John W Fondon, Harold R Garner
Sep 3, 2005·Evolution; International Journal of Organic Evolution·Gabriel Marroig, James M Cheverud
Sep 6, 2005·Molecular Genetics and Metabolism·Dobrawa NapieralaBrendan Lee
Sep 28, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Tania M SchroederJennifer J Westendorf
Jul 29, 2006·The American Naturalist·Anjali Goswami
Jul 28, 2007·The International Journal of Biochemistry & Cell Biology·Panos G ZirosAthanasios G Papavassiliou
Aug 19, 2008·The American Naturalist·R P FreckletonM Pagel
Apr 14, 2009·Journal of Human Evolution·Felipe Bandoni de OliveiraGabriel Marroig
Oct 7, 2009·Evolution; International Journal of Organic Evolution·Leandro R Monteiro, Marcelo R Nogueira
May 8, 2010·Science·Richard E GreenSvante Pääbo
Jun 22, 2010·Clinical Genetics·L HansenS Kreiborg
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marie ManceauHopi E Hoekstra
Aug 19, 2010·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Leila T Shirai, Gabriel Marroig
Oct 12, 2010·Molecular Biology and Evolution·Nicolas Lartillot, Raphaël Poujol
May 25, 2011·BMC Evolutionary Biology·Leandro R Monteiro, Marcelo R Nogueira
Nov 25, 2011·Proceedings. Biological Sciences·Elizabeth R DumontChristian C Voigt
Jun 30, 2012·BMC Evolutionary Biology·Marie A PointerBrenda J Bradley
Jul 28, 2012·Evolution; International Journal of Organic Evolution·Sharlene E SantanaElizabeth R Dumont
Oct 25, 2013·Evolution; International Journal of Organic Evolution·Arthur PortoGabriel Marroig
Jan 18, 2014·Evolution; International Journal of Organic Evolution·Elizabeth R DumontLiliana M Davalos
Apr 8, 2014·Nature Communications·Daisuke KoyabuMarcelo R Sánchez-Villagra
Jun 10, 2014·Journal of Proteome Research·Cecilia LindskogFredrik Pontén
Jul 9, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A GoswamiP D Polly
Nov 14, 2014·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Karen E Sears
May 12, 2015·Evolution; International Journal of Organic Evolution·Jeff J Shi, Daniel L Rabosky
Feb 13, 2016·Systematic Biology·Danny RojasLiliana M Dávalos
May 14, 2016·Proceedings. Biological Sciences·Sharlene E Santana, Elena Cheung
May 20, 2016·Nature Communications·Kaustubh AdhikariAndrés Ruiz-Linares

❮ Previous
Next ❯

Citations

Apr 17, 2020·BMC Molecular and Cell Biology·Axel H Newton, Andrew J Pask
Dec 15, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gabriel L GaleaPhilippa Francis-West
Feb 13, 2021·Genetics and Molecular Biology·Alexa SadierKaren E Sears

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

ENSEMBL
Codon Code Aligner
ClustalW
CoEvol
caper ” R package
R
NWM

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.