Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics

Anesthesia and Analgesia
Edmond I EgerJames M Sonner

Abstract

We hypothesized that N-methyl-d-aspartate (NMDA) receptors mediate some or all of the capacity of inhaled anesthetics to prevent movement in the face of noxious stimulation, and that this capacity to prevent movement correlates directly with the in vitro capacity of such anesthetics to block the NMDA receptor. To test this hypothesis, we measured the effect of IV infusion of the NMDA blockers dizocilpine (MK-801) and (R)-4-(3-phosphonopropyl) piperazine-2-carboxylic acid (CPP) to decrease the MAC (the minimum alveolar concentration of anesthetic that prevents movement in 50% of subjects given a noxious stimulation) of 8 conventional anesthetics (cyclopropane, desflurane, enflurane, halothane, isoflurane, nitrous oxide, sevoflurane, and xenon) and 8 aromatic compounds (benzene, fluorobenzene, o-difluorobenzene, p-difluorobenzene, 1,2,4-trifluorobenzene, 1,3,5-trifluorobenzene, pentafluorobenzene, and hexafluorobenzene) and, for comparison, etomidate. We postulated that MK-801 or CPP infusions would decrease MAC in inverse proportion to the in vitro capacity of these anesthetics to block the NMDA receptor. This notion proved correct for the aromatic inhaled anesthetics, but not for the conventional anesthetics. At the greatest in...Continue Reading

References

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Citations

Dec 7, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Masahiro IrifuneMichio Kawahara
Jun 8, 2012·BMC Anesthesiology·Robert J Brosnan, Roberto Thiesen
May 24, 2008·Anesthesia and Analgesia·Aubrey YaoJoseph F Antognini
Aug 21, 2008·Anesthesia and Analgesia·Edmond I EgerJames M Sonner
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guohua ZhangZhongcong Xie
Dec 18, 2013·European Journal of Pharmacology·Andrey B PetrenkoHiroshi Baba
Mar 31, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Xiaoyu ZhangXuan Zhao
Oct 24, 2006·Anesthesia and Analgesia·Yasumasa TanifujiJames M Sonner
Mar 23, 2007·Anesthesia and Analgesia·Joseph F AntogniniEarl Carstens
Apr 26, 2007·Anesthesia and Analgesia·Yi ZhangJames M Sonner
Apr 9, 2009·Expert Opinion on Pharmacotherapy·Fabrice Michel, Jean-Michel Constantin
Sep 16, 2018·BMC Pharmacology & Toxicology·Robert J Brosnan, Trung L Pham
Jun 27, 2019·Journal of Neurophysiology·Fahad IqbalNaweed I Syed

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