Contribution of (18)fluoro-deoxyglucose positron emission tomography to the work-up of patients with fever of unknown origin

European Journal of Internal Medicine
Ian BuysschaertDaniël Knockaert

Abstract

Background: Recent studies have suggested that (18)fluoro-deoxyglucose (FDG) positron emission tomography (PET) may be useful in the work-up of patients with fever of unknown origin (FUO), but its exact diagnostic yield has not been established. Methods: From January 1999 through December 2001, 74 (67%) of 110 prospectively collected patients who fulfilled the revised criteria of classic FUO underwent a FDG-PET scan. The diagnostic yield of this technique was assessed after diagnostic work-up and follow-up. Abnormal FDG-PET scans that pointed to the final diagnosis were categorized as helpful; all other scans were considered noncontributory. Results: A final diagnosis was established in 39 (53%) of the 74 patients who underwent FDG-PET. Fifty-three (72%) of the 74 FDG-PET scans were abnormal; 19 scans (36% of the abnormal scans or 26% of the total number of scans) were helpful. In the 39 patients with a final diagnosis, 49% of the scans were helpful. A diagnosis was established in 31 (58%) of the 53 patients with an abnormal scan and in 8 (38%) of the 21 patients with a normal scan (P=0.2). Baseline clinical variables (age and sex, as well as periodicity, duration, and height of the fever) and inflammatory parameters (erythrocy...Continue Reading

References

Nov 1, 1993·Journal of the American Geriatrics Society·D C KnockaertH J Bobbaers
Mar 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J V Hirschmann
Jun 9, 1998·The British Journal of Radiology·A M Peters
Sep 4, 1999·Lancet·F H Corstens, J W van der Meer
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D BlockmansL Mortelmans
Jul 17, 2001·Nuclear Medicine Communications·J LorenzenK H Bohuslavizki
Feb 1, 1961·Medicine·R G PETERSDORF, P B BEESON
Oct 11, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Chantal P Bleeker-RoversWim J G Oyen

❮ Previous
Next ❯

Citations

Apr 12, 2006·Der Orthopäde·M WelschF Grünwald
Mar 31, 2006·European Journal of Nuclear Medicine and Molecular Imaging·M Jaruskova, O Belohlavek
Jun 16, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Niklas JasperDirk Foell
Jun 28, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J CrouzetA Sotto
Feb 24, 2011·Annals of Nuclear Medicine·Kazuo KubotaKoji Murakami
Mar 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Athar HaroonJamshed Bomanji
Jan 11, 2011·QJM : Monthly Journal of the Association of Physicians·M FiskD J B Marks
Apr 15, 2011·International Journal of Molecular Imaging·Nurhan Ergül, Tevfik Fikret Cermik
Jan 15, 2013·International Journal of Molecular Imaging·H BalinkB L F van Eck-Smit
Aug 31, 2012·Clinical Medicine : Journal of the Royal College of Physicians of London·Raya ShpilbergS A Khan
Oct 18, 2007·Radiology·Daniel J A MargolisSanjiv S Gambhir
Dec 16, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Chantal P Bleeker-RoversWim J G Oyen
May 30, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Gijsbert J BlokhuisLioe-Fee de Geus-Oei
Jun 16, 2009·European Journal of Internal Medicine·Steven VanderschuerenDaniël D C Knockaert
Apr 3, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Florent L BessonEmmanuel Durand
Aug 17, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Rosa Moo-PucYolanda Freile-Pelegrin
Jul 7, 2012·European Journal of Radiology·Lin Qiu, Yue Chen
Sep 12, 2014·QJM : Monthly Journal of the Association of Physicians·A Gafter-GviliH Bernstine
Apr 29, 2015·Clinical Radiology·S VaidyanathanF U Chowdhury
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Si-Yuan PanKam-Ming Ko
Jul 6, 2014·La Presse médicale·Adrien RobinePascal Sève
Jun 28, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Bor-Tau HungChiung-Chih Chang
Oct 2, 2015·Nuclear Medicine Communications·Ashoka M V PereiraDaniel Franzen
Feb 9, 2010·Clinical Nuclear Medicine·Hans BalinkFilip Gemmel
Jul 17, 2010·Nuclear Medicine Communications·Pin Lin KeiAnthony S Goh
Nov 1, 2012·Der Internist·B SalzbergerM Müller-Schilling
Jul 2, 2011·Annals of the New York Academy of Sciences·Ora Israel, Zohar Keidar
Apr 1, 2015·European Journal of Clinical Investigation·Chrissa SiokaAndreas Fotopoulos
Mar 26, 2014·Clinical Nuclear Medicine·Hans BalinkHein J Verberne
Jul 19, 2012·Internal Medicine Journal·Y J KimM W Kang
Oct 3, 2018·Tropical Medicine and Infectious Disease·Narayan Gyawali, Andrew W Taylor-Robinson
Jun 27, 2012·AJR. American Journal of Roentgenology·Aftab Hasan NazarRakesh Kumar

❮ Previous
Next ❯

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