Contribution of acetylcholine, vasoactive intestinal polypeptide and nitric oxide to CNS-evoked vagal gastric relaxation in the rat

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Z K Krowicki, P J Hornby

Abstract

Several in vitro models of gastric relaxation have elucidated a role of nitric oxide (NO) and vasoactive intestinal polypeptide (VIP) in non-adrenergic, non-cholinergic (NANC) vagally mediated gastric relaxation. However, these models do not necessarily mimic the events leading to gastric relaxation in the whole animal. We have recently described a vagally mediated gastric relaxation evoked by micro-injection of substance P (SP) into the nucleus raphe obscurus (NRO). The present study was performed to elucidate whether this CNS-stimulated in vivo gastric relaxation involved acetylcholine, NO and VIP. Atropine (1 mg kg-1 i.v.), reduces both the rapid nadir and sustained gastric relaxation evoked by SP in the NRO, and the residual responses are abolished by NG-Nitro-L-arginine methyl ester hydrochloride (L-NAME, 10 mg kg-1 i.v.), an NO synthase inhibitor. Blockade of NO synthase alone is not sufficient to abolish the effect of SP into the NRO on intragastric pressure. A VIP antagonist, [p-chloro-D-Phe6, Leu17]VIP (32 micrograms i.v.) alone, or with the addition of L-NAME, does not affect the nadir of the gastric relaxation in response to SP microinjected into the NRO; however, both antagonists reduce the CNS-evoked sustained intr...Continue Reading

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Citations

Jun 5, 1999·European Journal of Pharmacology·Z K KrowickiP J Hornby
Jan 12, 1997·Journal of the Autonomic Nervous System·S Y YuanM Costa
Dec 2, 1999·Journal of the Autonomic Nervous System·Z K KrowickiP J Hornby
Mar 29, 2001·Autonomic Neuroscience : Basic & Clinical·S Panteleev, D Grundy
Jan 18, 2003·Autonomic Neuroscience : Basic & Clinical·Xueguo Zhang, Ronald Fogel
Feb 8, 2006·Annual Review of Physiology·R Alberto TravagliRichard C Rogers
Oct 2, 2001·The Journal of Physiology·M FerreiraR A Travagli
Jan 5, 2002·Canadian Journal of Physiology and Pharmacology·V C SmithA M Buchan
Feb 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J J GuoR A Travagli

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