Contribution of angiotensin I converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertension

American Journal of Hypertension
U F MondorfT Lenz

Abstract

The renin-angiotensin system (RAS) is involved in the pathogenesis of essential hypertension. In the present study we examined the genotype frequencies of the insertion/deletion polymorphisms of the ACE gene and the M235T polymorphism of the Angiotensinogen (Agt) gene in patients with essential hypertension in comparison with normotensive subjects. In hypertensive patients functional effects of blood pressure response to ACE inhibition were investigated. A total of 121 patients with essential hypertension (group 1) and 125 normotensive control subjects (group 2) were included in this study. All patients were genotyped by polymerase chain reactions (PCR) for the insertion/deletion (I/D) polymorphism of the ACE gene and the M235T polymorphism of the Agt gene. To analyze possible functional impacts on blood pressure regulation 50 mg of captopril was administered to hypertensive patients. No significant association of essential hypertension with polymorphisms of the Agt and ACE gene was found. The ACE serum levels in patients with the DD-genotype of the ACE I/D polymorphism were higher than in patients with the II-genotype (P < .01). In patients with the ID-genotype the ACE serum levels were in-between. A captopril test was perform...Continue Reading

Citations

Apr 1, 1999·Journal of Hypertension·J A StaessenR Fagard
Jul 3, 2007·Current Treatment Options in Cardiovascular Medicine·Agnieszka SlowikAndrzej Szczudlik
Dec 18, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Anke-Hilse Maitland-van der ZeeOlaf H Klungel
Nov 26, 2015·Nature Reviews. Nephrology·Rhonda M Cooper-DeHoff, Julie A Johnson
Jan 13, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Huimin YuGuozhang Liu
Jan 20, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Eiichi GeshiTakashi Katagiri
Jun 9, 2005·Journal of Hypertension·Philip B Mellen, David M Herrington
May 5, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Huimin YuWenjun Ma
Jan 22, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Haralampos J MilionisKostas C Siamopoulos
May 12, 2018·Circulation Research·Donna K Arnett, Steven A Claas
Jun 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Amar Akhtar SethiAnne Tybjaerg-Hansen
Jan 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Scott M WilliamsJason H Moore
Dec 3, 2003·Pharmacogenetics·Richard P KoopmansMartin C Michel
Nov 22, 2008·American Journal of Hypertension·Ines N HahntowMartin C Michel
Dec 17, 2008·Pharmacological Reviews·Dieter Rosskopf, Martin C Michel
Jan 28, 2010·Expert Opinion on Drug Metabolism & Toxicology·Kim TaverneOlaf Klungel
Feb 13, 2017·Molecular and Cellular Biochemistry·Egidio ImbalzanoGiuseppe Mandraffino
May 14, 2020·Archives of Physiology and Biochemistry·Babak HadianNegar Nouryazdan
Jan 31, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Dieter RosskopfRafael Schäfers
Jun 4, 2008·Current Opinion in Cardiology·Jasper J BrugtsMaarten L Simoons
Mar 18, 2021·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mingyu LiuWenwen Tang
Mar 7, 2001·The Journal of Molecular Diagnostics : JMD·D Crisan, J Carr

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