PMID: 3752268Sep 1, 1986Paper

Contribution of area postrema to pressor actions of angiotensin II in dog

The American Journal of Physiology
A OtsukaC M Ferrario

Abstract

To generate quantitative data on the contribution of the area postrema (AP) to the pressor activity of angiotensin II (ANG II), the peptide (7 ng X kg-1 X min-1) was infused intravenously in 10 conscious dogs for 6 h before, and several weeks after, AP lesion. Mean arterial pressure (MAP) and heart rate (HR) were recorded continuously, and plasma renin activity (PRA), ANG II immunoreactivity (ANG II-IR), aldosterone (ALDO), arginine vasopressin (AVP), norepinephrine (NE), epinephrine (EPI), and serum Na+ and K+ were measured at 3 and 6 h. Three hours into the infusion, MAP averaged 123 +/- 2 compared with 96 +/- 2 mmHg for controls (P less than 0.01). The increases in pressure were associated with unchanged HR, but increased lability of MAP and HR. PRA fell, whereas plasma levels of ANG II-IR and ALDO rose. Plasma levels of AVP, NE, serum Na+ and K+ did not change, but plasma EPI was significantly elevated at 6 h. Removal of the AP produced mild hypotension and decreased lability. Within 8 to 21 days after AP ablation, a significant decrease in the plateau phase (3-6 h) of the ANG II pressor response was recorded in all dogs. The attenuation of the pressor effects was not sustained, since 4-7 wk after AP lesion, the increases i...Continue Reading

Citations

Jan 1, 1989·Circulation Research·C J TsengD Robertson
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Max G Sanderford, Vernon S Bishop
Jan 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaya PamidimukkalaMeredith Hay
Mar 1, 1996·Hypertension·D B AverillC M Ferrario

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