PMID: 6167332Aug 24, 1981Paper

Contribution of axonal transport to the renewal of myelin phospholipids in peripheral nerves. II. Biochemical study

Brain Research
M BrunettiB Droz

Abstract

The classes of radioactive phospholipids appearing in the ciliary ganglion (CG) and especially in the myelin sheath of the intraorbital part of the oculomotor nerve (OMN) were determined after the intracerebral injection of [2-3H]glycerol and [methyl-14C]choline to chickens. Analysis of the radioactive compounds in water-soluble fractions and chloroform-methanol extracts was performed by thin-layer chromatography (TLC). The water-soluble content of the OMN and CG was much poorer in [2-3H]glycerol and metabolites than in [methyl-14C]choline and derivatives. All classes of glycerophospholipids were found to be axonally transported along the OMN and into the CG, but choline-phosphoglycerides (CPG) were largely predominant. In myelin fractions from the OMN, the specific radioactivity (SRA) of CPG labeled with [2-3H]glycerol reached a maximum earlier (40 h) than the SRA of CPG labeled with [methyl-14C]choline. A 25-fold enhancement of the [14C]SRA of sphingomyelin (SM) was observed between 12 h and 7 days. These results indicate that: (1) axonally transported phospholipids labeled with [2-3H]glycerol consist mainly of CPG; (2) small amounts of CPG are translocated from the axon to myelin; and (3) the progressive enrichment of myelin...Continue Reading

References

Mar 1, 1979·Journal of Neurochemistry·J E Haley, R W Ledeen
Apr 1, 1979·Journal of Neurochemistry·A D ToewsP Morell
Apr 1, 1979·Biochemical Society Transactions·S Spanner, G B Ansell
Feb 1, 1979·Journal of Neurochemistry·M BrunettiG Porcellati
Mar 1, 1976·The Journal of Cell Biology·R M Gould, R M Dawson
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Nov 6, 1969·Biochemical and Biophysical Research Communications·R L Wykle, F Snyder
Jan 1, 1969·The Journal of Cell Biology·W J Hendelman, R P Bunge

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Citations

Jan 1, 1987·Acta Neuropathologica·C E BlanchardG Allt
Jan 1, 1987·Neurochemical Research·M BrunettiA Gaiti
Aug 1, 1990·Journal of the Neurological Sciences·H YoshikawaC Giannini
Dec 1, 1985·Journal of Neurochemistry·M A Bisby
Dec 1, 1982·Journal of Neurochemistry·R M GouldN A Ingoglia
Jan 1, 1985·Progress in Lipid Research·P S Sastry

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