PMID: 11604077Oct 18, 2001Paper

Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response

Radiation Research
Terry JennerPeter O'Neill

Abstract

Biophysical modeling of radiation-induced DNA damage shows that significant yields of clustered DNA damage are formed after energy deposition by a single radiation track. To date, the majority of studies on radiation-induced DNA damage in cells have concentrated on determination of the yields of single- and double-strand breaks (DSBs), the latter representing one type of clustered DNA damage. It was recognized, however, that clustered DNA damage, which does not contain a DSB, might contain a combination of DNA base lesions and single-strand breaks in proximity. This mini-review discusses some of the recent experimental data confirming the induction of non-DSB, clustered DNA damage by radiation.

References

Sep 1, 1988·International Journal of Radiation Biology·C R PaulH C Box
Nov 1, 1988·International Journal of Radiation Biology·D Blöcher
Jan 1, 1988·Progress in Nucleic Acid Research and Molecular Biology·J F Ward
Jun 23, 1995·Journal of Molecular Biology·M A Chaudhry, M Weinfeld
May 1, 1993·International Journal of Radiation Biology·D T GoodheadR Cox
Sep 1, 1993·International Journal of Radiation Biology·T J JennerD L Stevens
Jul 4, 1998·International Journal of Radiation Biology·R HanaiK Hieda
Aug 26, 1998·International Journal of Radiation Biology·K M PriseB Stenerlöw
Jun 29, 1999·Radiation and Environmental Biophysics·H NikjooD T Goodhead
Jul 9, 1999·Journal of Molecular Biology·L HarrisonS S Wallace
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·B M SutherlandJ Laval
Apr 15, 2000·The Journal of Biological Chemistry·M H David-CordonnierP O'Neill

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Citations

Dec 30, 2009·Radiation and Environmental Biophysics·Liming Zhang, Zhenyu Tan
Jul 1, 2009·International Journal of Biological Sciences·C David WoodMercedes Rincon
Aug 7, 2009·Molecular Biology of the Cell·Chiaw-Hwee LimYun-Jin Jiang
Dec 7, 2006·International Journal of Radiation Biology·Jonathan LoreeOlga Kovalchuk
Sep 14, 2010·Seminars in Radiation Oncology·Conchita Vens, Adrian C Begg
Sep 1, 2007·The Journal of Investigative Dermatology·Julie ShorrocksTrevor J McMillan
Mar 21, 2015·International Journal of Radiation Biology·Adnan M Ikhtiar
May 15, 2002·Radiation Research·Betsy M SutherlandJacques Laval
Mar 25, 2011·Nature Reviews. Cancer·Adrian C BeggConchita Vens
Nov 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chantal CourtemancheBruce N Ames
Feb 2, 2017·Oncotarget·Zubaidah M RamdzanAlain Nepveu
Feb 24, 2006·Radiation Research·Lorenzo MantiJonathan Bradley Court
Feb 17, 2009·Journal of Radiation Research·Naoya ShikazonoAkinari Yokoya
Aug 3, 2019·International Journal of Molecular Sciences·Yi Zheng, Léon Sanche
Apr 17, 2008·Journal of Radiation Research·Megumi Hada, Alexandros G Georgakilas

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