Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine

The European Journal of Neuroscience
G TandaG Di Chiara

Abstract

This study was performed to investigate the relative role of noradrenaline (NA) and dopamine (DA) carrier blockade in the effects of psychostimulants on DA transmission in the rat prefrontal cortex (PFCX). To this end, changes of extracellular DA and NA in the PFCX and of extracellular DA in the nucleus accumbens (NAc) were measured following the administration of amphetamine and cocaine, which are known to bind to both DA and NA carriers, or GBR 12909, a selective DA carrier blocker. After non-intravenous injection, amphetamine (0.25 and 0.5 mg/kg, s.c.) and cocaine (5 and 10 mg/kg, i.p.) increased extracellular DA in the PFCX to a larger extent than in the NAc, while the reverse applied to GBR 12909 (2.5 and 5 mg/kg, i.p.). These differences were obtained in spite of the fact that the three drugs elicited at each dose level a similar peak increase of extracellular DA in the NAc. Amphetamine and cocaine also increased extracellular NA in the PFCX and this effect was quantitatively similar to that on extracellular DA in the same area. Intravenous doses of cocaine and GBR 12909, corresponding to those which maintain self-administration in the rat, while equieffective in raising extracellular DA in the NAc, had different effects ...Continue Reading

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Citations

Dec 3, 2011·Psychopharmacology·Petra J J Baarendse, Louk J M J Vanderschuren
Apr 26, 2006·Cellular and Molecular Neurobiology·Piotr PopikAnthony S Basile
Nov 13, 2003·European Journal of Pharmacology·Beatriz A Rocha
Apr 20, 2000·European Journal of Pharmacology·G Di Chiara
Jul 6, 2002·European Journal of Pharmacology·Annalisa PinnaMicaela Morelli
Aug 12, 1999·European Journal of Pharmacology·G Di Chiara
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·G Tanda, S R Goldberg
Oct 26, 1999·Trends in Neurosciences·R Spanagel, F Weiss
Nov 26, 2002·Behavioural Brain Research·Gaetano Di Chiara
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Mar 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elise MoriceMarika Nosten-Bertrand
Dec 18, 2002·Journal of Neurochemistry·Masato InazuTeruhiko Matsumiya
Aug 4, 2001·Behavioural Pharmacology·M G LanserA R Cools
Jun 23, 2012·Pharmacogenetics and Genomics·Anne Tammimäki, Pekka T Männistö
Jul 23, 1999·Annals of the New York Academy of Sciences·G Di ChiaraE Carboni
Apr 13, 2011·Journal of Psychiatry & Neuroscience : JPN·Cecilia Flores
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea BariTrevor W Robbins
Jan 19, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrea OssatoMatteo Marti
Nov 22, 2002·Journal of Neuroscience Research·Michaël RougemontVincent Castagné
Oct 20, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gianluigi Tanda
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Dec 16, 2006·Neuroscience Letters·Zhixia WangWilliam Woolverton
Apr 30, 2014·CNS Neuroscience & Therapeutics·Sylvia NavaillesPhilippe De Deurwaerdère

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