Contribution of bone-marrow-derived cells to choroidal neovascularization

Biochemical and Biophysical Research Communications
Hidenori TakahashiMasataka Sata

Abstract

We investigated the involvement of bone-marrow derived cells to experimental choroidal neovascularization (CNV) in mice, whose bone marrow was reconstituted by either unfractionated bone-marrow cells or Lin-c(-)Kit(+)Sca-1+ enriched presumable hematopoietic stem cells from the green fluorescent protein (GFP) transgeneic mice. Immunohistochemical analysis demonstrated the presence of GFP-positive cells in the CNV lesion after unfractionated bone-marrow transplantation, as well as Lin-c(-)Kit(+)Sca-1+ cell transplantation. Some of the GFP-expressing cells also expressed CD-31 and PanEC antigen, markers of vascular endothelial cells. Our results suggest that bone-marrow derived cells may contribute endothelial cells in CNV.

References

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Citations

Jul 22, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hui-Yuan HouYan Cai
Aug 17, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hidenori TakahashiYasuhiro Tamaki
Jul 26, 2008·Progress in Retinal and Eye Research·J S PennM E Hartnett
Jun 16, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Guodong SongGeorge F Murphy
Jun 16, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Lee M MorrisTimothy M Crombleholme
May 26, 2011·Seminars in Ophthalmology·Georges M El-MollayessZiad F Bashshur
Dec 19, 2019·Frontiers in Pharmacology·Natalie Jia Ying YeoChristine Cheung

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