PMID: 7536881Jan 1, 1995Paper

Contribution of bradykinin to heat-induced substance P release in the hind instep of rats

Life Sciences
N YoneharaR Inoki

Abstract

To investigate the possible contribution of the bradykinin (BK) system to heat-induced substance P (SP) release from the peripheral endings of primary afferent nerves, we used the high molecular weight (HMW) and low molecular weight (LMW) kininogen-deficient rat strain (Brown Norway-Katholiek, B/N-Ka) and the normal rat strain (Brown Norway-Kitasato, B/N-Ki). We found that immersion of the paw of B/N-Ki rats in water of 47 degrees C for 20 min led to significant increases of BK, SP and Evans blue extravasation in the s.c. perfusate, and that similar treatment resulted in significantly lower levels in B/N-Ka rats. Local application of BK (10(-4) M) to the s.c. perfusate and intra-arterial infusion of BK 10(-5) mol/kg) increased Evans blue extravasation and SP release evoked by heat stimulation, respectively, in B/N-Ka rats to similar levels to those in B/N-Ki rats after heat-stimulation without BK treatment. These results indicate that BK released into the extravascular space by noxious stimulation is involved in SP release from the peripheral endings of capsaicin-sensitive primary sensory neurons.

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Citations

Mar 18, 2000·Neuroscience Research·N Yonehara, M Yoshimura
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sophie PezetStephen B McMahon
May 22, 2010·The Journal of Pharmacy and Pharmacology·Jie LiCang-Bao Xu
Apr 21, 2009·Brain Research·Nicole M E CarmichaelJonathan O Dostrovsky

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