PMID: 7514234Jan 1, 1993Paper

Contribution of bradykinin to the cardiovascular effects of ramipril

Journal of Cardiovascular Pharmacology
W LinzB A Schölkens

Abstract

From pharmacologic investigations and clinical studies it is known that angiotensin-converting enzyme (ACE) inhibitors exhibit additional local actions, which are not related to hemodynamic changes and which cannot be explained simply by interference with the renin-angiotensin system with subsequent inhibition of angiotensin II formation. Because ACE is identical to kininase II, which inactivates the nonapeptide bradykinin (BK), potentiation of BK might be responsible for these additional effects of ACE inhibitors. To prove the specificity of BK-mediated effects by ACE inhibition, we used the specific B2 kinin receptor antagonist HOE 140 in different models: endothelial cell cultures; atherosclerosis in high-cholesterol-fed rabbits; neointima formation with smooth cell proliferation and migration after endothelial denudation in rats; myocardial ischemia in rats, rabbits, and dogs; and left ventricular hypertrophy in rats. The beneficial effects of ramipril or BK given in non-blood pressure-lowering doses in these models were abolished by HOE 140 (icatibant). Ramipril exerts cardioprotective effects in different experimental models. The formation of the endothelial autacoids nitric oxide and prostacyclin, enhanced when BK degrad...Continue Reading

Citations

Feb 1, 1997·Journal of the American College of Cardiology·F PerticoneP L Mattioli
Jul 11, 2000·Journal of Molecular and Cellular Cardiology·A C RosenkranzR H Ritchie
Oct 1, 1996·Journal of the American College of Cardiology·C Rosendorff
Feb 7, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jin Bo Su
Mar 23, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J F Mann
Dec 25, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuyuki Shimada, Metin Avkiran
May 9, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuyuki ShimadaNobuo Kitamura

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