Contribution of carboxyl modified chiral mesoporous silica nanoparticles in delivering doxorubicin hydrochloride in vitro: pH-response controlled release, enhanced drug cellular uptake and cytotoxicity

Colloids and Surfaces. B, Biointerfaces
Jing LiSanming Li

Abstract

In this study, dual functionalized mesoporous silica nanoparticle (Dual-MSN) with functions of carboxyl modification and chirality was successfully developed and its special contribution in delivering doxorubicin hydrochloride (DOX) in vitro was mainly studied. Characteristics of Dual-MSN and its application as DOX carrier were intensively explored by comparing with naked non-functionalized MSN (Naked MSN). The results indicated that both Naked MSN and Dual-MSN significantly controlled DOX release due to the release hindrance caused by mesopores. As expected, Dual-MSN exhibited obvious enhanced pH-response because of its negative charges of carboxyl groups. DOX loaded Naked MSN and DOX loaded Dual-MSN presented better cytotoxicity than DOX due to carrier-mediated endocytosis and the favorable intercalation of DOX into DNA in the nuclei. The cytotoxicity of DOX loaded Dual-MSN was better than DOX loaded Naked MSN owing to its enhanced cellular uptake induced by chirality of Dual-MSN, demonstrating that double functions of Dual-MSN had unique advantages in improving antitumor effect of DOX towards MCF-7 cells and thus confirming its special contribution in DOX delivery.

References

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Oct 30, 2014·ACS Applied Materials & Interfaces·Shreya GoelWeibo Cai
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Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Jing LiSanming Li
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Jing LiSanming Li

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Citations

Jul 14, 2016·Chemistry, an Asian Journal·Xiaozhong Qu, Zhenzhong Yang
Dec 10, 2016·Biomaterials Science·Jingchao LiGuoping Chen
Aug 5, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Jing LiSanming Li
Aug 9, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Nan ZhengLu Xu
Aug 17, 2018·Photochemistry and Photobiology·Goutam GhoshAlexander Greer
Mar 17, 2020·Chemical Society Reviews·Xueli ZhaoXiaoyuan Chen
Jun 17, 2020·Drug Development and Industrial Pharmacy·Zibin GaoYanping Sun
Feb 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhua ZhuQunwei Xu
Oct 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yingyu GuoHeran Li
Oct 10, 2018·ACS Applied Materials & Interfaces·Indu TripathiDipanjan Pan
Aug 28, 2018·Bioconjugate Chemistry·Li LuoGui-Xue Wang

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