PMID: 9160854Apr 1, 1997Paper

Contribution of caudal brainstem to d-fenfluramine anorexia

Psychopharmacology
H J GrillJ M Kaplan

Abstract

Of the central 5-HT substrates that may mediate the anorexic actions of systemically administered d-fenfluramine (d-FEN), those in the forebrain have received the most attention. As a counterpoint to this forebrain focus, we evaluated the contribution of caudal brainstem substrates to the anorexic action of d-FEN. Two experimental protocols were employed. In one we compared the feeding response (intra-oral intake of 12.5% glucose) of intact and chronic supracollicular decerebrate (CD) rats to systemic administration of d-FEN. In the other, d-FEN was administered via fourth intracerebroventricular (ICV) injection to determine whether a dose-related suppression of intra-oral intake could be obtained. A dose-dependent suppression of intra-oral intake was obtained in the CD rat treated with d-FEN (0-8 mg/kg, delivered IP 20 min before testing). The threshold dose was two to three times higher in CD rats than in their intact controls, but the dynamic range of the dose-response curves of the two groups were overlapping with similar slopes of decline and with comparable maximal intake suppression. Fourth ICV administration of d-FEN in the intact rat yielded a dose-related suppression of intra-oral intake. Intake was also suppressed by...Continue Reading

Citations

Feb 19, 1999·Brain Research·N E Rowland, R M Richmond
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Kenny J Simansky, Danielle M Nicklous
Jun 2, 2006·Psychosomatic Medicine·Barton J BlinderVisant A Sanathara
Jun 22, 2000·Hormones and Behavior·J E SchneiderR M Blum
Sep 15, 2010·Pharmacology, Biochemistry, and Behavior·Daniel D LamLora K Heisler
Nov 3, 2010·Nutritional Neuroscience·Carolina Peixoto MagalhãesRaul Manhães de Castro
Mar 22, 2002·Frontiers in Neuroendocrinology·Harvey J Grill, Joel M Kaplan
Jul 19, 2006·Neuron·Lora K HeislerMichael A Cowley
Nov 7, 2007·Cell Metabolism·Laurence H Tecott
Sep 15, 2014·Behavioural Brain Research·Jörg-Peter Voigt, Heidrun Fink
Jul 28, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zachary S RobertsJames E Blevins
Sep 25, 2012·Journal of Veterinary Science·Morteza ZendehdelRamin Mazaheri Nezhad Fard
Nov 27, 2018·Physiological Reviews·Lindsey A Schier, Alan C Spector
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Lori Asarian, Thomas Bächler
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N E RowlandA T Cespedes

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