Contribution of CCK1 receptors to cardiovascular and respiratory effects of cholecystokinin in anesthetized rats

Neuropeptides
Katarzyna Kaczyńska, Małgorzata Szereda-Przestaszewska

Abstract

The study investigated the share of vagal input at infra- and supra-nodosal level and the contribution of CCK1 and CCK2 receptors to the cardiorespiratory responses produced by an intravenous injection of sulfated cholecystokinin octapeptide (CCK-8) in anesthetized rats. This compound administered intravenously at a dose of 50μg/kg induced short-lived decline in tidal volume and respiratory rate resulting in depression of minute ventilation. Midcervical vagotomy had no effect on CCK-8-evoked ventilatory changes, whereas supranodosal denervation abolished slowing down of breathing. Cardiovascular response to CCK challenge was characterized by a transient decrease followed by an augmentation in the mean blood pressure (MAP) in the intact animals. Vagotomy performed at both levels abrogated the declining phase of MAP. Blood pressure changes were associated with decreased heart rate present in all neural states. All cardiovascular and respiratory effects were antagonized by pre-treatment with devazepide-CCK1 receptors' antagonist, whereas CI988-antagonist of CCK2 receptors was ineffective. In conclusion, our results indicate that CCK-8 modulates slowing down of respiratory rhythm via CCK1 receptors located in the nodose ganglia (NG...Continue Reading

References

Dec 1, 1990·Journal of the Autonomic Nervous System·L A Blackshaw, D Grundy
Mar 1, 1988·Regulatory Peptides·J D Marker, M L Roberts
Jan 1, 1985·Annals of the New York Academy of Sciences·M Denavit-SaubiéJ Champagnat
Nov 26, 1985·European Journal of Pharmacology·M HurléM Denavit-Saubié
Jun 1, 1997·Progress in Neurobiology·H ZhuoC J Helke
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniela M Sartor, Anthony J M Verberne
May 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
Nov 12, 2005·Experimental Physiology·Katarzyna Kaczyñska, Malgorzata Szereda-Przestaszewska
Nov 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V BaptistaR A Travagli
May 29, 2007·Experimental Physiology·Malgorzata Szereda-Przestaszewska, Katarzyna Kaczyńska
Nov 6, 2007·Current Medicinal Chemistry·Ying Li
Jul 29, 2008·Brain Research Reviews·Daniela M Sartor, Anthony J M Verberne
Jan 26, 2010·Respiratory Physiology & Neurobiology·Katarzyna Kaczyńska, Małgorzata Szereda-Przestaszewska
Jan 22, 2013·Frontiers in Neuroscience·Michael C AndresenMackenzie E Hofmann

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Citations

Dec 9, 2016·European Journal of Clinical Investigation·Federico CarboneFabrizio Montecucco
Dec 23, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicole M Cancelliere, Alastair V Ferguson
Oct 15, 2019·Frontiers in Neuroscience·Jonathan Gorky, James Schwaber
Nov 30, 2018·JAMA Cardiology·Kelsie E OatmenFrancis G Spinale
Jun 6, 2018·Cellular and Molecular Neurobiology·Wen Yi JiangZong Jie Cui

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