Contribution of CD4+, CD8+CD28+, and CD8+CD28- T cells to CD3+ lymphocyte homeostasis during the natural course of HIV-1 infection

The Journal of Clinical Investigation
A CarusoA Turano

Abstract

The relationship between the number of circulating CD4+ T cells and the presence of particular CD8+ T cell subsets was analyzed by flow cytometry on PBL from asymptomatic HIV-1-infected patients whose specimens were collected every 2 mo for a total period of 32 mo. Only slight variations were detected in the absolute number of lymphocytes and percentage of CD3+ lymphocytes, whereas both CD4+ and CD8+ T cell subsets showed wide intrapatient variation. Variations in the number of CD8+CD28+ cells paralleled those of the CD4+ T cell subset in each patient tested, while the presence of CD8+CD28- T cells correlated inversely with CD4+ and CD8+CD28+ T cells. These data show that changes in the number of circulating CD4+-and CD8+CD28+ T cells are strongly related to the presence of CD8+CD28- T cells in these patients. Insight into the significance of CD8+CD28- T cell expansion will allow us to understand the mechanisms and significance of the HIV-1- driven change in CD4+CD8+ T cell homeostasis and the basic immunopathology of HIV disease.

References

Dec 1, 1992·The Journal of Infectious Diseases·A P van den BergL H de Leij
Aug 1, 1991·Immunology Today·S Romagnani
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J FantiniJ C Chermann
Jan 1, 1992·The Journal of Experimental Medicine·C Van KerckhoveM B Brenner
Aug 1, 1985·Transplantation·A R ZanderE M Hersh
Jul 14, 1973·Lancet·P K PattengaleP Gerber
Dec 1, 1995·Nature Medicine·A AmadoriL Chieco-Bianchi
Jul 1, 1995·Nature Medicine·M Roederer
Aug 1, 1995·Scandinavian Journal of Immunology·G Boll, J Reimann
Jan 1, 1995·Immunology Today·C FranceschiA Cossarizza
Nov 1, 1994·Scandinavian Journal of Immunology·A CarusoA Balsari

❮ Previous
Next ❯

Citations

Mar 26, 2004·Nature Reviews. Immunology·Janko Nikolich-ZugichIlhem Messaoudi
Feb 26, 2000·Clinical and Experimental Immunology·H Choremi-PapadopoulouT Kordossis
Mar 1, 2002·Immunology and Cell Biology·Fernando A Arosa
Oct 21, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Giulio AlessandriArnaldo Caruso
Nov 15, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Loic DesquilbetUNKNOWN Multicenter AIDS Cohort Study
Jan 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Weiwei CaoRoger Detels
May 7, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hemant KulkarniVincent C Marconi
Feb 27, 2004·Immunology and Cell Biology·Jane GambergMichael Grant
Jun 6, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Seema H BajariaDenise Kirschner
Oct 17, 2008·The Open AIDS Journal·Naveed GulzarKaren F T Copeland
Oct 18, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A CarusoA Turano
Jun 20, 2003·European Journal of Clinical Investigation·S ResinoMa A Muñoz-Fernández
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S FiorentiniA Caruso
Dec 22, 1999·Clinical and Experimental Immunology·S R SøndergaardB K Pedersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.