PMID: 12788191Jun 6, 2003Paper

Contribution of conformal therapy in the treatment of anal canal carcinoma with combined chemotherapy and radiotherapy: results of a phase II study

International Journal of Radiation Oncology, Biology, Physics
Té VuongGyorgy Hegyi

Abstract

To evaluate the feasibility of delivering conformal radiotherapy (RT) and concurrent chemotherapy without a mandatory break in patients with anal canal carcinoma. Thirty patients with T2-T4 tumors were treated with a combination of 54 Gy in 30 fractions and two cycles of 5-fluorouracil and mitomycin C. Dose-volume histograms were obtained for bone marrow, small bowel, and skin to compare the conventional technique using the Radiation Therapy Oncology Group standard with our conformal technique. The mean dose ratio of the conventional compared with the conformal technique for bone marrow, small bowel, and skin was, respectively, 2.1-2.7, 3.0, and 2.0, in favor of the conformal technique. All patients completed their treatment without a treatment break. An incidence of Grade 3 toxicity for bone marrow, bowel, and skin of 13.3%, 3.3%, and 20%, respectively, was observed. With a median follow-up of 33 months, a 4-year local recurrence-free survival rate of 91% was observed. The results of this study have shown that conformal RT leads to a well-tolerated treatment. The treatment time is shortened to 6 weeks. A significant decrease in the acute toxicity rate suggests that by decreasing the "volume factor," conformal RT improves the t...Continue Reading

References

Mar 11, 1976·American Journal of Surgery·G T Golden, J S Horsley
Jun 1, 1991·Diseases of the Colon and Rectum·N D Nigro
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B J CummingsC N Catton
May 1, 1987·Diseases of the Colon and Rectum·J Papillon, J F Montbarbon
May 1, 1974·Diseases of the Colon and Rectum·N D NigroB Considine
Mar 1, 1970·American Journal of Surgery·E R RatzerE L Frazell
Nov 1, 1968·Cancer·P G KuehnJ F Reed
Dec 1, 1984·American Journal of Clinical Oncology·M AjlouniM P Milad
Oct 1, 1982·Diseases of the Colon and Rectum·B SischyJ E Woll
Feb 1, 1995·American Journal of Clinical Oncology·R J MyersonI Kodner
Jun 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T A RichB Levin
Jan 1, 1996·Clinical Oncology : a Journal of the Royal College of Radiologists·D M BottomleyR H Phillips
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·D PeiffertF Baylac
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·E C ConstantinouT F DeLaney
May 8, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J P GerardF Mornex
Jun 8, 2001·International Journal of Radiation Oncology, Biology, Physics·D C WeberA S Allal
Oct 2, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R J MyersonB J Walz
Jan 1, 1996·International Journal of Radiation Oncology, Biology, Physics·M JohnN Palma
Dec 1, 1948·Archives of Surgery·J E DUNPHY

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Citations

Aug 4, 2009·International Journal of Colorectal Disease·Stefan JanssenAndreas Meyer
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesUNKNOWN ESMO Guidelines Working Group
Mar 8, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F AbbasakoorP B Boulos
Nov 20, 2014·Practical Radiation Oncology·Kurian JosephPatricia Tai
Jan 28, 2016·Nature Reviews. Clinical Oncology·Rob Glynne-JonesPeter Hoskin
Nov 3, 2012·Hematology/oncology Clinics of North America·Rob Glynne-Jones, Andrew Renehan
Apr 24, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ajay AggarwalRob Glynne-Jones
Nov 10, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kurian Jones JosephJohn Pedersen
May 4, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Tsang CheungPeter K N Yu
Aug 1, 2015·Journal of Medical Radiation Sciences·Elizabeth BrownMichael Ng
Sep 21, 2016·Best Practice & Research. Clinical Gastroenterology·A Vinayan, R Glynne-Jones
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics·Té VuongCarolyn Freeman
Jul 21, 2016·American Journal of Clinical Oncology·Hilary P BagshawGeorge M Cannon
Jan 15, 2014·Hospital Pharmacy·Brittany N WhiteDominic A Solimando
Nov 24, 2004·Physics in Medicine and Biology·Martin J ButsonPeter K N Yu
Dec 9, 2004·Physics in Medicine and Biology·Tsang CheungPeter K N Yu
Jun 8, 2006·Physics in Medicine and Biology·Martin J ButsonPeter K N Yu
Jul 21, 2005·Physics in Medicine and Biology·Martin J ButsonPeter K N Yu
Jan 20, 2015·Journal of Medical Radiation Sciences·Alison CraySarat Chander
May 26, 2018·Journal of Medical Imaging and Radiation Oncology·Kurian JosephKeith Tankel
Mar 19, 2011·International Journal of Radiation Oncology, Biology, Physics·Rob Glynne-Jones, Faye Lim

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