PMID: 9178193May 1, 1997Paper

Contribution of cytochrome P450 3A pathway to bromocriptine metabolism and effects of ferrous iron and hypoxia-re-oxygenation on its elimination in the perfused rat liver

The Journal of Pharmacy and Pharmacology
K MatsubayashiY Fukui

Abstract

The contribution of the cytochrome P450 3A pathway to bromocriptine metabolism, and the effects of ferrous iron and hypoxia-re-oxygenation on its elimination, were evaluated with the perfused rat liver. Outflow profiles of bromocriptine after bolus administration were estimated by moment analysis and dispersion model analysis. Kinetic parameters were not significantly changed by troleandomycin, a P450 3A inhibitor. The inhibition of bromocriptine metabolism by troleandomycin was 5.7 +/- 2.4%. These findings indicate that cytochrome P450 3A does not play an important role in bromocriptine elimination with the perfused rat liver. Elimination rate constant (ka) values were significantly increased by ferrous iron perfusion or hypoxia-re-oxygenation. Free-radical generation can, therefore, affect bromocriptine elimination. Our observations suggest that bromocriptine might be eliminated by scavenging of free radicals in the liver.

References

Apr 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Jan 6, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M J CoonA D Vaz
Jan 1, 1991·Pharmacology & Therapeutics·R E White
Jun 1, 1991·Biochemical Pharmacology·T HijiokaT Kamada
Nov 1, 1990·The Journal of Clinical Investigation·G K BysaniJ R Hoidal
Feb 1, 1989·Japanese Journal of Pharmacology·S M MoochhalaG Becket
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G J GoresN F LaRusso
Jun 1, 1986·Journal of Pharmacokinetics and Biopharmaceutics·M S Roberts, M Rowland
Sep 15, 1985·Biochemical Pharmacology·R N WilliamsC A Paterson
Jul 1, 1985·Biopharmaceutics & Drug Disposition·H F SchranS I Bhuta
Mar 29, 1983·Biochemical and Biophysical Research Communications·J R BucherS D Aust
Jan 1, 1983·European Journal of Drug Metabolism and Pharmacokinetics·G MaurerA P Shukla
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P CaraceniD H Van Thiel
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·M S Paller, H S Jacob
Mar 1, 1994·Journal of Neurochemistry·T YoshikawaM Kondo

❮ Previous
Next ❯

Citations

Apr 10, 2013·Expert Opinion on Drug Metabolism & Toxicology·José A G AgúndezFélix Javier Jiménez-Jiménez
Feb 26, 2016·Expert Opinion on Drug Metabolism & Toxicology·Félix Javier Jiménez-JiménezJosé A G Agúndez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.