Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells

Journal of Cardiovascular Pharmacology
Xie-hong LiuChao-ke Tang

Abstract

Adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a crucial role in apolipoprotein A-I (apoA-I) binding activity and promotes cellular cholesterol efflux. ApoA-I mimetic peptide D4-F has reported to have the similar ability as apoA-I. However, the detailed mechanisms of ABCA1 regulation by D4-F are not understood. In the present study, we investigated the effects of D4-F on ABCA1 expression and ABCA1-dependent cholesterol efflux and examined the role of Cdc42/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway on the regulation of ABCA1 by D4-F in THP-1 macrophage-derived foam cells. Results showed that D4-F stabilized ABCA1 protein and enhanced ABCA1-dependent cholesterol efflux but had no effect on ABCA1 messenger RNA expression. We also revealed that D4-F enhanced cAMP level and PKA activity and ABCA1 serine phosphorylation. Short interfering RNA of PKA led to reduction of ABCA1 serine phosphorylation and ABCA1-mediated cholesterol efflux compensated by D4-F. PKA-specific activation by PKA agonist enhanced the upregulation of ABCA1 serine phosphorylation and ABCA1-mediated cholesterol efflux by D4-F. However, ABCA1 expression did not change by treatment with PKA agonist or PKA-short interf...Continue Reading

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Citations

May 28, 2013·DNA and Cell Biology·Yun-cheng LvChao-ke Tang
Aug 5, 2015·Molecular Medicine Reports·Wei SongXiaowei Yan
Jul 22, 2014·Clinical and Translational Science·Kai Yin, Devendra K Agrawal
Feb 7, 2012·Atherosclerosis·Wu-Jun ChenChao-Ke Tang
Sep 14, 2010·Acta Pharmacologica Sinica·Di-xian LuoDuan-fang Liao
Apr 16, 2020·Biomolecules·Olivier MeilhacDavid Couret
Aug 6, 2020·International Journal of Molecular Sciences·En-Shyh LinLei Wan
Jan 29, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jin ZouChaoke Tang

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