PMID: 6403747Jan 1, 1983Paper

Contribution of dialysate acetate to energy metabolism: metabolic implications

Kidney International
C L SkutchesG A Reichard

Abstract

During hemodialysis large amounts of acetate enter the bloodstream. Generally, it is assumed that this exogenous acetate load is oxidized immediately to carbon dioxide and water; however, the rate of plasma acetate oxidation and the effect of acetate oxidation on energy metabolism during hemodialysis has not been determined previously. The rates of plasma acetate turnover and oxidation were determined during hemodialysis in seven chronic renal failure patients by the primed continuous infusion of [1-14C] acetate. The plasma acetate turnover rate (57.2 +/- 2.9 mumoles/min X kg) agreed closely with the mass transfer rate of dialysate acetate into the bloodstream (55.3 +/- 3.2 mumoles/min X kg). Of the acetate entering the bloodstream, 54.5 +/- 5.2% or 31.6 +/- 3.77 mumoles/min X kg was oxidized immediately accounting for 40.3 +/- 4.8% of the patient's caloric expenditure. Although the oxidation of acetate during dialysis supplied a major portion of the patient's caloric need, a significant quantity of acetate was eliminated by pathways other than direct oxidation. An average overall respiratory quotient (RQ) of 1.0 +/- 0.02 indicated that fat oxidation was spared to maintain energy homeostasis during hemodialysis. The calculated ...Continue Reading

References

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Citations

Jul 1, 1995·Diseases of the Colon and Rectum·I SegalJ Braganza
Nov 1, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·A O AkanjiS Humphreys
Jun 23, 2001·Biochimica Et Biophysica Acta·H YamashitaK Tagawa
Apr 9, 1992·The New England Journal of Medicine·P M SuterE Jequier
Apr 1, 1988·The Journal of Clinical Investigation·J J ShelmetG Boden
Jan 25, 2013·Nutrients·Ian B Jeffery, Paul W O'Toole
Dec 1, 1986·Kidney International·Y BouffardJ Motin
Sep 30, 2005·Hemodialysis International·M CapdevilaL I Juncos
Apr 29, 2015·Molecular BioSystems·Mohamad Hafizi Abu BakarHarisun Yaakob
Aug 15, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Vittorio ScaravilliAndriy I Batchinsky
May 31, 2019·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Jamie Rasmussen, David M Duriancik
Jun 16, 1999·Journal of Applied Physiology·L A Bertocci, B F Lujan
May 1, 1995·The American Journal of Physiology·C T PutmanG J Heigenhauser

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