Contribution of Drosophila DEG/ENaC genes to salt taste

Neuron
Lei LiuMichael J Welsh

Abstract

The ability to detect salt is critical for the survival of terrestrial animals. Based on amiloride-dependent inhibition, the receptors that detect salt have been postulated to be DEG/ENaC channels. We found the Drosophila DEG/ENaC genes Pickpocket11 (ppk11) and Pickpocket19 (ppk19) expressed in the larval taste-sensing terminal organ and in adults on the taste bristles of the labelum, the legs, and the wing margins. When we disrupted PPK11 or PPK19 function, larvae lost their ability to discriminate low concentrations of Na(+) or K(+) from water, and the electrophysiologic responses to low salt concentrations were attenuated. In both larvae and adults, disrupting PPK11 or PPK19 affected the behavioral response to high salt concentrations. In contrast, the response of larvae to sucrose, pH 3, and several odors remained intact. These results indicate that the DEG/ENaC channels PPK11 and PPK19 play a key role in detecting Na(+) and K(+) salts.

References

Sep 28, 1990·Science·T R Scott, B K Giza
Jul 31, 1990·Neuroscience Letters· Kovalchuk YuNM C Nowycky
Jan 1, 1985·Cold Spring Harbor Symposia on Quantitative Biology·G M RubinCharles S Zuker
Jul 1, 1988·The Journal of General Physiology·S MiersonJ A DeSimone
Nov 27, 1981·Science·J A DeSimoneS K DeSimone
Aug 1, 1995·Physiology & Behavior·N J van der Klaauw, D V Smith
Aug 1, 1996·Current Opinion in Neurobiology·S C Kinnamon, R F Margolskee
Mar 13, 1997·Nature·R WaldmannM Lazdunski
Jan 1, 1997·Annual Review of Physiology·N Tavernarakis, Monica Driscoll
Oct 27, 1997·The Journal of Biological Chemistry·Christopher M AdamsMichael J Welsh
Dec 31, 1997·The Journal of Biological Chemistry·E LinguegliaM Lazdunski
Dec 19, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O KretzB Lindemann
Dec 23, 1998·Neuroscience and Biobehavioral Reviews·B P Halpern
Mar 17, 1999·The Journal of Comparative Neurology·W LinS C Kinnamon
Apr 1, 1999·Annual Review of Physiology·M S Herness, T A Gilbertson
Jul 10, 1999·The Journal of General Physiology·S KellenbergerL Schild
Aug 10, 2000·Nature Biotechnology·J R Kennerdell, R W Carthew
Apr 13, 2001·Neuron·D P Smith
Mar 5, 2002·Nature·Miriam B GoodmanMartin Chalfie

Citations

May 17, 2011·Invertebrate Neuroscience : in·H Schuppe, P L Newland
Jun 21, 2013·Nature Communications·Sandhya CharluAnupama Dahanukar
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shilpa SwarupRobert R H Anholt
Feb 18, 2010·The Journal of Biological Chemistry·Stefan DürrnagelStefan Gründer
Oct 31, 2006·Chemical Senses·Bertram Gerber, Reinhard F Stocker
Jun 15, 2013·Science·Yali V ZhangCraig Montell
Dec 8, 2005·Annual Review of Entomology·Elissa A HallemJohn R Carlson
May 18, 2007·Annual Review of Neuroscience·Leslie B Vosshall, Reinhard F Stocker
Apr 21, 2007·Annual Review of Nutrition·Alexander A Bachmanov, Gary K Beauchamp
Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric LazartiguesRobin L Davisson
Jul 15, 2011·American Journal of Physiology. Renal Physiology·Ossama B Kashlan, Thomas R Kleyman
Mar 3, 2010·PloS One·Yehuda Ben-ShaharMichael J Welsh
May 15, 2013·PloS One·Isabelle DevambezLaurent Soustelle
Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tong LiuClaudio W Pikielny
Mar 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elena StarostinaClaudio W Pikielny
Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Heping LinClaudio W Pikielny
May 17, 2014·Chemical Senses·Christian KönigBertram Gerber
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yehuda Ben-ShaharMichael J Welsh
Feb 13, 2016·Nature Communications·Lena van GiesenSimon G Sprecher
Mar 19, 2014·Nutrition·Robert I Henkin
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yushu ChenMartin Chalfie
Apr 20, 2014·Science China. Life Sciences·Fei SunLi Liu
Mar 12, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Qin OuyangTadashi Nakamura
Sep 20, 2008·Current Opinion in Neurobiology·Richard Benton
Dec 5, 2015·Frontiers in Integrative Neuroscience·Alice FrenchFrédéric Marion-Poll
Nov 4, 2015·Frontiers in Integrative Neuroscience·Anthi A ApostolopoulouAndreas S Thum
Apr 17, 2007·The Journal of Comparative Neurology·Julien ColombReinhard F Stocker
Apr 20, 2007·Developmental Neurobiology·H SchuppeP L Newland
Nov 5, 2005·Neuron·Kristin Scott
Sep 25, 2004·Journal of Neurobiology·Makoto HiroiTeiichi Tanimura
Jun 24, 2015·Current Opinion in Neurobiology·Erica Gene Freeman, Anupama Dahanukar
Jan 13, 2006·The EMBO Journal·Renate K HukemaGert Jansen
Aug 27, 2013·Neuron·Meg A YoungerGraeme W Davis
Mar 13, 2014·Neuron·Emily R LimanCraig Montell
Mar 4, 2014·Insect Biochemistry and Molecular Biology·Jackson T SparksJoseph C Dickens
Sep 6, 2005·Current Biology : CB·Hubert Amrein, Natasha Thorne
Oct 26, 2013·Insect Biochemistry and Molecular Biology·Jackson T SparksJoseph C Dickens
Sep 6, 2003·Current Biology : CB·Joshua A AinsleyWayne A Johnson
Feb 18, 2015·Chemical Senses·Gunjan H AryaRobert R H Anholt
Oct 20, 2009·Cell·David A YarmolinskyNicholas J P Ryba
Feb 1, 2008·Developmental Biology·Michèle Crozatier, Alain Vincent
Oct 18, 2014·Cellular and Molecular Life Sciences : CMLS·Robert J Lee, Noam A Cohen
Aug 4, 2016·Frontiers in Cellular Neuroscience·Jaekyun ChoiJae Young Kwon
Jan 30, 2014·Memórias do Instituto Oswaldo Cruz·Jose Manuel Latorre-EstivalisMarcelo Gustavo Lorenzo
Nov 16, 2017·Scientific Reports·Agustina CanoRomina B Barrozo
Sep 10, 2014·American Journal of Rhinology & Allergy·Robert J Lee, Noam A Cohen
Jul 13, 2018·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Mark C HarrisonCoby Schal
Sep 14, 2004·Journal of Neurobiology·David M Tobin, Cornelia I Bargmann
Dec 11, 2007·The Journal of Comparative Neurology·Natasha Thorne, Hubert Amrein
May 28, 2010·Insect Molecular Biology·R P DaleD B Sattelle
Feb 1, 2013·Nature·Marios ChatzigeorgiouWilliam R Schafer
May 24, 2012·Biological Reviews of the Cambridge Philosophical Society·Thomas D Förster, H Arthur Woods
Aug 5, 2020·Molecular Biology and Evolution·Joel VizuetaAlejandro Sánchez-Gracia
Aug 27, 2017·The Journal of Comparative Neurology·Anna Rist, Andreas S Thum
Nov 28, 2018·Journal of Experimental Neuroscience·Shivam KaushikPinky Kain
Oct 9, 2018·Frontiers in Physiology·Jackson T SparksJoseph C Dickens
Mar 2, 2013·G3 : Genes - Genomes - Genetics·Kathleen M ZelleYehuda Ben-Shahar
May 14, 2016·G3 : Genes - Genomes - Genetics·Yushu ChenMartin Chalfie
Feb 5, 2020·EMBO Reports·Natsune TakagakiAtsushi Kuhara

Related Concepts

Kaluril
Metazoa
Behavior, Animal
Drosophila
Electrophysiology (Science)
Embryonic Structures, Nonmammalian
Tadpole
Afferent Neuron
Salts
Taste Perception

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

© 2021 Meta ULC. All rights reserved