Contribution of dynamic vascular wall thickening to luminal narrowing during coronary arterial constriction

Circulation
R N MacAlpin

Abstract

Available estimates of the ratio of wall thickness to luminal radius of human coronary arteries and certain geometrical assumptions were used to calculate the amounts of vascular smooth muscle shortening required to produce specific changes in luminal diameter for hypothetical "normal" and stenotic arteries. The results indicate that even modest mural thickening due to disease may act as a "lever" in translating physiologic degrees of medial smooth muscle shortening into critical luminal obstructions, providing the diseased segment maintains some pliability. The possibility of acute luminal occlusion occurring at stenotic sites as the result of "normal" vasomotion is illustrated. The appropriate use of the term coronary arterial "spasm" is discussed in light of these observations.

References

Jan 1, 1979·The American Journal of Cardiology·R L FeldmanC R Conti
Apr 1, 1978·The American Journal of Cardiology·F A HeuplerW C Sheldon
Apr 1, 1978·Japanese Circulation Journal·E KimuraA Kuroiwa
May 1, 1976·The American Journal of Cardiology·C B HigginsJ S Schroeder
Mar 1, 1968·Circulation·Z Vlodaver, H N Neufeld
Jul 1, 1968·Circulation Research·T E CarewD J Patel
Apr 1, 1969·Circulation·Z VlodaverH N Neufeld
Apr 1, 1962·Circulation Research·R L VAN CITTERSR F RUSHMER
Sep 1, 1959·The American Journal of Medicine·M PRINZMETALN BOR
Nov 10, 1951·Lancet·G W PICKERING

❮ Previous
Next ❯

Citations

Apr 30, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Tsung O Cheng
Apr 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·C G SobeyO L Woodman
May 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C W Buffington
Dec 5, 2006·Heart and Vessels·Masamichi WadaMasato Nakamura
Jun 27, 1983·The American Journal of Medicine·M McGregor
May 1, 1989·Physiology & Behavior·D A Kirby, R L Verrier
Sep 1, 1985·International Journal of Cardiology·T von ArnimA Maseri
Sep 1, 1989·Journal of the American College of Cardiology·A HoshioH Mashiba
Apr 1, 1991·Journal of the American College of Cardiology·H MashibaH Kotake
Apr 1, 1996·Journal of the American College of Cardiology·J K SongS J Park
Oct 1, 1991·Trends in Cardiovascular Medicine·J C Kaski
Sep 13, 1980·Lancet
Oct 2, 1982·Lancet·K M FoxA P Selwyn
Mar 1, 1991·Journal of the American College of Cardiology·J C KaskiA Maseri
May 1, 1985·Journal of the American College of Cardiology·T CorcosD D Waters
Mar 1, 1985·Journal of the American College of Cardiology·P ThérouxD D Waters
Feb 1, 1987·Journal of the American College of Cardiology·A Maseri
May 20, 1999·Journal of the American College of Cardiology·J F BeltrameA Maseri
Jan 1, 1994·Eye·H C ChenE M Kohner
Nov 1, 1987·Clinical and Experimental Pharmacology & Physiology·O L Woodman
May 1, 1991·Clinical and Experimental Pharmacology & Physiology·C G SobeyO L Woodman
Aug 31, 2000·Coronary Artery Disease·P KaufmannO M Hess
Sep 15, 2000·Japanese Heart Journal·O SunagawaK Fukiyama
Jan 3, 2015·International Journal of Cardiology·Rex N MacAlpin
Jul 23, 2008·Neuropharmacology·Antoinette MaassenVanDenBrinkCarlos M Villalón

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.