Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes

European Journal of Pharmacology
Vannina G MarrachelliEnrique Alborch

Abstract

The influence of diabetes on regulatory mechanisms and specific receptors implicated in the response of isolated rabbit renal artery to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was less potent in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal or N(G)-nitro-L-arginine (L-NOARG) enhanced contractions to endothelin-1 either in control and diabetic arteries. Indomethacin inhibited endothelin-1-induced response in control arteries, but enhanced it in diabetic arteries. In contrast to that observed in rubbed and in L-NOARG treated arteries, in the presence of indomethacin the contractile action of endothelin-1 was higher in diabetic arteries than in control arteries. Nimesulide enhanced endothelin-1 contractions both in control and diabetic arteries. Cyclo-(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123, endothelin ET(A) receptor antagonist), attenuated endothelin-1 vasoconstriction in control rabbits, while vasoconstriction resulted increased in diabetic rabbits. 2,6-Dimethylpiperidinecarbonyl-gamma-Methyl-Leu-N(in)-(Methoxycarbonyl)-D-Trp-D-Nle (BQ-788, endothelin ET(B) receptor antagonist), enhanced the contractile response in control rabbit arteries ...Continue Reading

References

Jul 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J A RimarachinB B Weksler
Jan 1, 1996·Diabetes·A G NugentG D Johnston
Jan 1, 1995·Journal of Cardiovascular Pharmacology·H C LamL J Hao
Feb 1, 1997·Journal of Applied Physiology·R HaberbergerW Kummer
Jan 29, 2000·Diabetologia·R L Hopfner, V Gopalakrishnan
Jul 6, 2000·British Journal of Pharmacology·A S De VrieseP M Vanhoutte
Nov 15, 2000·Journal of Cardiovascular Pharmacology·H C NoraG A Rae
Mar 29, 2001·European Journal of Pharmacology·J A AlabadíE Alborch
Mar 19, 2002·Hypertension·Masaru MiyatakaRichard J Bing
Apr 9, 2002·European Journal of Pharmacology·Francisco J MirandaEnrique Alborch
Jun 18, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Layton Harris SmithDouglas E Vaughan
Sep 24, 2002·Pharmacology & Therapeutics·P D'Orléans-JusteJ C Honoré
Mar 27, 2003·American Journal of Physiology. Renal Physiology·Valentina CâmpeanSebastian Bachmann
Sep 5, 2003·American Journal of Physiology. Renal Physiology·Andrey Sorokin, Donald E Kohan
Dec 18, 2003·American Journal of Physiology. Renal Physiology·Armin JustWilliam J Arendshorst
Feb 27, 2004·European Journal of Pharmacology·José A AlabadíEnrique Alborch

❮ Previous
Next ❯

Citations

Aug 18, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vannina G MarrachelliEnrique Alborch
Dec 14, 2011·Behavioural Brain Research·Mohammad Reza ZarrindastMohammad Nasehi
Dec 21, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Claudia Roberta de AndradeAna Maria de Oliveira
Sep 21, 2013·Behavioural Brain Research·Nasrin HosseiniMohammad-Reza Zarrindast

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Neurología : publicación oficial de la Sociedad Española de Neurología
A L Márquez-AguirreF J Gálvez-Gastélum
© 2022 Meta ULC. All rights reserved