Contribution of environmental toxins in the pathogenesis of idiopathic cardiomyopathies

Current Treatment Options in Cardiovascular Medicine
Antonio L Perez, W H Wilson Tang

Abstract

The pathogenesis of idiopathic cardiomyopathies is likely highly complex and remains elusive. Environmental toxins have been hypothesized to possibly cause a subset of cardiomyopathies. Epidemiological, preclinical, and small clinical studies have investigated the role of numerous elements and compounds in the pathogenesis of these myocardial disorders. In this review, we present the evidence implicating elements and environmental compounds in myocardial toxicity, including antimony, cobalt, mercury, aluminum, copper, and acrolein. We discuss their sources, toxic effects, and epidemiology, as well as identify groups at risk for toxic exposure. Through our discussion, we highlight areas where further investigation into the clinical effects of these possible toxins is warranted.

References

Jan 1, 1971·British Heart Journal·Y MorinG Mercier
Jan 31, 1969·Annals of the New York Academy of Sciences·Y MorinG Mercier
Jul 1, 1965·American Industrial Hygiene Association Journal·B Bromberger-Barnea, N L Stephens
Jan 1, 1995·Reviews of Environmental Contamination and Toxicology·D P Ghilarducci, R S Tjeerdema
Oct 1, 1996·Biological Trace Element Research·J A CentenoR Virmani
Sep 25, 1999·Toxicology and Applied Pharmacology·J E SnawderM Toraason
Jan 20, 2000·Trends in Cardiovascular Medicine·K Uchida
Aug 30, 2000·Lancet·M P Rayman
Aug 11, 2001·Journal of Toxicology and Environmental Health. Part a·P K SouthA D Smith
Jan 5, 2002·Scandinavian Journal of Clinical and Laboratory Investigation·N ClyneR Wibom
May 13, 2003·Environmental Toxicology·Paul B TchounwouDwayne Sutton
Oct 14, 2003·Biological Trace Element Research·Gamze TopuzogluNaciye Yensel
Jan 13, 2005·British Journal of Pharmacology·Marco AlvarezJacques M Lignon
Aug 4, 2007·Congestive Heart Failure·Leslie T CooperNicholas V C Ralston
Dec 14, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Joshua Schier, Adam Algren
Mar 11, 2008·Toxicology and Applied Pharmacology·Amanda S Persad, Glinda S Cooper
Jun 24, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Richard Y Wang
Oct 7, 2008·The Journal of Arthroplasty·Marcus OldenburgXaver Baur
May 12, 2010·Circulation·Robert D BrookUNKNOWN American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Coun
Jul 10, 2010·Current Atherosclerosis Reports·Robert D Brook, Sanjay Rajagopalan
Feb 15, 2011·International Journal of Environmental Research and Public Health·Shyam Sundar, Jaya Chakravarty
Sep 13, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Mohamed Ameen IsmahilSumanth D Prabhu
Oct 11, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer F NylandEllen K Silbergeld
Feb 23, 2012·Chemical Research in Toxicology·Hans-Juergen Haussmann
Apr 24, 2012·Heart, Lung & Circulation·Colin MachadoRobert Wood
Jan 12, 2013·Atherosclerosis·Kenta WatanabeItsuko Ishii
Jan 15, 2013·The Canadian Journal of Cardiology·Cameron J GilbertChristopher Overgaard
Jul 3, 2013·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Christiaan P van LingenCees C P M Verheyen
Aug 8, 2014·Journal of the American Heart Association·Natasha DeJarnettAruni Bhatnagar

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Citations

Sep 28, 2018·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Philippe Hantson
Jun 3, 2021·International Journal of Environmental Research and Public Health·Didier Malamba-LezDophra Ngoy-Nkulu

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