Contribution of Extracellular Vesicles in Rebuilding Injured Muscles.

Frontiers in Physiology
Daniel C Bittel, Jyoti K Jaiswal

Abstract

Skeletal myofibers are injured due to mechanical stresses experienced during physical activity, or due to myofiber fragility caused by genetic diseases. The injured myofiber needs to be repaired or regenerated to restore the loss in muscle tissue function. Myofiber repair and regeneration requires coordinated action of various intercellular signaling factors-including proteins, inflammatory cytokines, miRNAs, and membrane lipids. It is increasingly being recognized release and transmission of these signaling factors involves extracellular vesicle (EV) released by myofibers and other cells in the injured muscle. Intercellular signaling by these EVs alters the phenotype of their target cells either by directly delivering the functional proteins and lipids or by modifying longer-term gene expression. These changes in the target cells activate downstream pathways involved in tissue homeostasis and repair. The EVs are heterogeneous with regards to their size, composition, cargo, location, as well as time-course of genesis and release. These differences impact on the subsequent repair and regeneration of injured skeletal muscles. This review focuses on how intracellular vesicle production, cargo packaging, and secretion by injured mu...Continue Reading

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Citations

Mar 14, 2020·Biomolecules·Marietta HerrmannFranz Jakob
Sep 30, 2019·Journal of Muscle Research and Cell Motility·Ngoc Thien LamJennifer L Strande
Jun 17, 2020·The American Journal of Sports Medicine·Shama R IyerRichard M Lovering
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Aug 8, 2020·International Journal of Molecular Sciences·Adam J BittelYi-Wen Chen
Sep 18, 2020·International Journal of Molecular Sciences·Stefania FochiMaria Grazia Romanelli
Feb 15, 2020·Journal of Orthopaedic Surgery and Research·Ashim GuptaNicola Maffulli
Oct 4, 2020·Bioengineering·Gregory ReidMichela Pozzobon
Aug 7, 2021·Journal of Personalized Medicine·Oihane Pikatza-MenoioSonia Alonso-Martín

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Methods Mentioned

BETA
transgenic
GTPases
acylation

Software Mentioned

SwissPalm
CLMotif

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