Contribution of flow cytometry to the diagnosis of malignant and non malignant conditions in lymph node biopsies

Leukemia & Lymphoma
Christophe RavoetBernard Husson

Abstract

In order to assess the contribution of FC to the diagnosis of lymph node disorders we retrospectively compared the pathological and the FC diagnosis made in 118 consecutive lymph node biopsies. Pathological diagnosis included non malignant conditions (n = 43), B-cell Non Hodgkin lymphoma (NHL) (n = 30), T-cell NHL (1 case), carcinoma (n = 18), Hodgkin lymphoma (HL) (n = 15), melanoma (n = 2), chronic myelocytic leukemia (n = 12), miscellaneous non-lymphoid tissues (n = 6) and undetermined conditions (n = 2). Among the 116 assessable samples, FC was in agreement with histology in 102 cases (87.9%; 95%CI = 81-93) which included 38 benign conditions (90%; 95% CI = 77-97%), 29 NHL (96.7%; 95% CI = 83-100), 18 carcinomas (100%; 95% CI = 81-100), and 12 HL (80.0%; 95% CI = 52-96). Discrepancies (14 cases) included 3 HL undiagnosed by FC and 2 granulomatous adenitis with an erroneous FC diagnosis of HL. Finally, a malignant condition was suspected only by FC in 5 cases (1 carcinoma, 2 B-cell and 2 T-cell NHL) and subsequently demonstrated by additional diagnostic procedures. In conclusion, this study confirms that FC performed on fresh lymph node samples is a powerful diagnostic tool in patients with malignant lymphoma. A few cases le...Continue Reading

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Citations

Sep 10, 2005·CytoJournal·Michael W Beaty, Kim R Geisinger
Mar 18, 2011·American Journal of Clinical Pathology·Anna DemurtasAlessandra Stacchini
May 24, 2012·Diagnostic Cytopathology·Ben DavidsonBjörn Risberg
Dec 24, 2005·Pathology·Emma J Gudgin, Wendy N Erber
Apr 19, 2013·American Journal of Clinical Pathology·Vinodh PillaiDavid M Dorfman
Mar 30, 2017·International Journal of Surgical Pathology·Omonigho AisagbonhiAmy Ly
Feb 14, 2008·Cytometry. Part B, Clinical Cytometry·David S BoslerMarc D Smith
Apr 21, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Immacolata CozzolinoPio Zeppa

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