Contribution of frontostriatal function to sequence learning in Parkinson's disease: evidence for dissociable systems

Neuroreport
P Dominey, M Jeannerod

Abstract

The frontostriatal system appears to play a crucial role in the organization and execution of sequential behaviour, but the precise nature of its contribution remains to be specified. From this perspective, relatively simple modifications of behavioural task parameters may invoke rather profound changes in the recruitment of appropriate neural mechanisms, including the frontostriatal system. This mini-review examines how variations in task requirements for sequence learning and related cognitive tasks can induce significant modifications in the performance of patients with Parkinson's disease. In particular, these observations are used to support a developing argument for neurophysiologically dissociable sequence learning systems in man. One of these mechanisms is sensitive to surface structure, or element-by-element sequence organization, and appears to rely on the frontostriatal system. Another sequence learning mechanism is sensitive to abstract structure, or relationships between repeating sequence elements, and appears to be largely independent of the frontostriatal system.

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Citations

Dec 19, 2009·Experimental Brain Research·Hiroko Mochizuki-KawaiMitsuru Kawamura
Apr 14, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sonja A KotzMaren Schmidt-Kassow
Jan 28, 2004·Neuropsychology·James H HowardChandan J Vaidya
Sep 18, 2004·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·John G MiltonAna Solodkin
Dec 1, 1998·Journal of Cognitive Neuroscience·P F DomineyM Jeannerod
Jul 7, 2009·Neuroreport·Sebastian PilgrammKaren Zentgraf
Sep 29, 2005·Neuroreport·Ya-Wei ChengJen-Chuen Hsieh
Jul 14, 2000·Physiological Reviews·O HikosakaR Kawagoe
Jul 21, 2017·NPJ Parkinson's Disease·Daniele CaligioreGianluca Baldassarre

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