Contribution of galanin to stress-induced impairment of insulin secretion in swimming mice

Acta Physiologica Scandinavica
B E DunningB Ahrén

Abstract

This study examines the potential role of the neuropeptide, galanin, in stress-induced inhibition of insulin secretion in swimming mice. Firstly, the pancreatic and adrenal content of galanin-like immunoreactivity was determined in mice after swimming stress. It was found that pancreatic content was significantly lower in stressed mice than in resting controls, both after 2 (P less than 0.05) and 6 (P less than 0.025) minutes of swimming, suggesting partial release of pancreatic galanin during stress. In contrast, the adrenal content of galanin-like immunoreactivity did not change during the swimming stress. Gel filtration of tissue extracts indicated that (1) mouse pancreas contains two forms of galanin-like immunoreactivity; one co-eluting with synthetic porcine galanin (centered on Kav of 0.70) and another with a larger molecular weight (centered on Kav of 0.30), and (2) mouse adrenal contains a small void volume-peak and a larger peak of immunoreactivity, the latter co-eluting with synthetic galanin. Secondly, the effects of swimming stress on plasma glucose and insulin levels were compared in mice that received high titre rabbit anti-galanin serum with those in mice receiving normal rabbit serum. In normal rabbit serum-pre...Continue Reading

References

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May 1, 1991·Cell and Tissue Research·S LindskogF Sundler
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Citations

May 1, 1991·Cell and Tissue Research·S LindskogF Sundler
Jun 23, 1994·European Journal of Pharmacology·S GregersenB Ahrén
Oct 1, 1997·Physiology & Behavior·M Milot, F Trudeau
Oct 1, 1993·Acta Physiologica Scandinavica·B E Dunning, B Ahrén
Jul 1, 1997·The Journal of Clinical Investigation·Z L WangS R Bloom
Oct 9, 2014·The Journal of Clinical Investigation·Hana VakiliPeter A Cattini
Oct 6, 2000·Endocrine Research·I N LegakisT Mountokalakis
Jun 1, 1992·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·B Ahrén, S Lindskog

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