Contribution of galanin to stress-induced impairment of insulin secretion in swimming mice

Acta Physiologica Scandinavica
B E DunningB Ahrén


This study examines the potential role of the neuropeptide, galanin, in stress-induced inhibition of insulin secretion in swimming mice. Firstly, the pancreatic and adrenal content of galanin-like immunoreactivity was determined in mice after swimming stress. It was found that pancreatic content was significantly lower in stressed mice than in resting controls, both after 2 (P less than 0.05) and 6 (P less than 0.025) minutes of swimming, suggesting partial release of pancreatic galanin during stress. In contrast, the adrenal content of galanin-like immunoreactivity did not change during the swimming stress. Gel filtration of tissue extracts indicated that (1) mouse pancreas contains two forms of galanin-like immunoreactivity; one co-eluting with synthetic porcine galanin (centered on Kav of 0.70) and another with a larger molecular weight (centered on Kav of 0.30), and (2) mouse adrenal contains a small void volume-peak and a larger peak of immunoreactivity, the latter co-eluting with synthetic galanin. Secondly, the effects of swimming stress on plasma glucose and insulin levels were compared in mice that received high titre rabbit anti-galanin serum with those in mice receiving normal rabbit serum. In normal rabbit serum-pre...Continue Reading


Aug 11, 1990·Acta Physiologica Scandinavica·S LindskogB Ahrén
May 1, 1991·Cell and Tissue Research·S LindskogF Sundler
Jul 1, 1990·Metabolism: Clinical and Experimental·S Karlsson, B Ahrén
Mar 1, 1991·Journal of the Autonomic Nervous System·S Karlsson, B Ahrén
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A Rökaeus, M J Brownstein
Dec 1, 1986·The Journal of Clinical Endocrinology and Metabolism·F E BauerS R Bloom
Mar 1, 1987·Acta Physiologica Scandinavica·S Lindskog, B Ahrén
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L M KaplanW W Chin
Sep 1, 1988·Diabetes·B E Dunning, G J Taborsky
Apr 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·S Lindskog, B Ahrén
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Oct 1, 1983·Journal of the Autonomic Nervous System·P H Smith, B J Davis

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May 1, 1991·Cell and Tissue Research·S LindskogF Sundler
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