Contribution of glutathione to the control of cellular redox homeostasis under toxic metal and metalloid stress

Journal of Experimental Botany
Luis E HernándezCarolina Escobar

Abstract

The accumulation of toxic metals and metalloids, such as cadmium (Cd), mercury (Hg), or arsenic (As), as a consequence of various anthropogenic activities, poses a serious threat to the environment and human health. The ability of plants to take up mineral nutrients from the soil can be exploited to develop phytoremediation technologies able to alleviate the negative impact of toxic elements in terrestrial ecosystems. However, we must select plant species or populations capable of tolerating exposure to hazardous elements. The tolerance of plant cells to toxic elements is highly dependent on glutathione (GSH) metabolism. GSH is a biothiol tripeptide that plays a fundamental dual role: first, as an antioxidant to mitigate the redox imbalance caused by toxic metal(loid) accumulation, and second as a precursor of phytochelatins (PCs), ligand peptides that limit the free ion cellular concentration of those pollutants. The sulphur assimilation pathway, synthesis of GSH, and production of PCs are tightly regulated in order to alleviate the phytotoxicity of different hazardous elements, which might induce specific stress signatures. This review provides an update on mechanisms of tolerance that depend on biothiols in plant cells expos...Continue Reading

References

Feb 27, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·J F Briat, M Lebrun
Aug 16, 2000·Environmental Research·G J MyersT W Clarkson
Jan 2, 2001·Journal of Inorganic Biochemistry·M NakayamaT Hase
May 5, 2001·Annual Review of Plant Physiology and Plant Molecular Biology·Ian M Moller
Dec 13, 2001·Journal of Experimental Botany·J L Hall
May 9, 2002·Journal of Experimental Botany·Andres Schützendübel, Andrea Polle
Jul 18, 2002·Trends in Plant Science·Stephan ClemensUte Krämer
Sep 12, 2002·Annual Review of Plant Biology·Christopher Cobbett, Peter Goldsbrough
Jan 30, 2004·Annual Review of Medicine·Herbert Needleman
Feb 6, 2004·British Medical Bulletin·Lars Järup
Jul 20, 2004·Journal of Experimental Botany·Peter BuchnerMalcolm J Hawkesford
Aug 3, 2004·Journal of Experimental Botany·Stanislav Kopriva, Heinz Rennenberg
Sep 18, 2004·Plant Physiology·Kazuki Saito
Oct 7, 2004·Trends in Plant Science·Ron MittlerFrank Van Breusegem
Dec 14, 2004·Environmental Research·Ana Paula Souza LimaRegina Celi Sarkis Müller
Jun 9, 2005·EMBO Reports·Andreas D Peuke, Heinz Rennenberg
Jul 6, 2005·Journal of Experimental Botany·Cristina Ortega-VillasanteLuis E Hernández
Sep 7, 2005·Trends in Plant Science·Thomas Rausch, Andreas Wachter
May 16, 2006·Plant Physiology·Fabio F NocitoGian Attilio Sacchi
Jun 13, 2006·The Journal of Biological Chemistry·Michael HothornKlaus Scheffzek
Jul 11, 2006·The Journal of Biological Chemistry·Ning-Hui ChengKendal D Hirschi
Oct 5, 2006·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Simon KapajProsun Bhattacharya
Dec 7, 2006·Plant Biotechnology Journal·José R Domínguez-SolísCecilia Gotor
Jan 25, 2007·The New Phytologist·Frank Van BelleghemRoland Valcke
Feb 9, 2007·Trends in Plant Science·Geert PottersMarcel A K Jansen
Feb 13, 2007·Trends in Plant Science·Graham NoctorChristine H Foyer
Feb 24, 2007·The Plant Journal : for Cell and Molecular Biology·Naoko Ohkama-OhtsuDavid J Oliver
Aug 8, 2007·Journal of the Neurological Sciences·Shigeo EkinoToshinori Kitamura
Sep 7, 2007·The New Phytologist·Cristina Ortega-VillasanteRamón O Carpena-Ruiz

❮ Previous
Next ❯

Citations

Jan 18, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arbace OfficiosoCaterina Manna
Jan 3, 2016·Current Opinion in Plant Biology·Hironaka Tsukagoshi
Feb 13, 2016·Frontiers in Plant Science·Els KeunenAnn Cuypers
Mar 1, 2016·Free Radical Biology & Medicine·Narciso CoutoJill Barber
Apr 17, 2016·Environmental Science and Pollution Research International·Michela SchiavonFrancesca Dalla Vecchia
Sep 11, 2016·Chemico-biological Interactions·Aurélie JacquartNguyet-Thanh Ha-Duong
Oct 19, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiefeng YeZhiqi Shi
Dec 17, 2016·Environmental Science & Technology·Anne-Marie AucourGéraldine Sarret
Oct 27, 2017·Acta chirurgica Belgica·Farzin SafaeiMehdi Goudarzi
Jan 8, 2020·Environmental Science and Pollution Research International·Eleonora CoppaEnrico Santangelo
Mar 7, 2020·International Journal of Environmental Research and Public Health·Silvia DíazAna Martín-González
Sep 11, 2019·Environmental Science and Pollution Research International·Hardik Naik JinalNatarajan Amaresan
Jun 1, 2018·BioMed Research International·Abolghassem EmamverdianSirous Sangari
Sep 22, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Loriana Demecsová, Ladislav Tamás
Oct 24, 2019·Ecology and Evolution·Xiang GaoHong Chen
May 23, 2019·AoB Plants·Waldemar Viana Andrade JúniorAnderson de Santana Botelho
Sep 22, 2018·Physiologia Plantarum·Sara TrevisanSilvia Quaggiotti
Dec 14, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·M Aydın AkbudakKubra Kontbay
Mar 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudia BonechiClaudio Rossi
Jun 23, 2018·Frontiers in Plant Science·Smita Kumar, Prabodh K Trivedi
Sep 7, 2019·Journal of Food Biochemistry·Mehmet Selim Ağır, Gökhan Eraslan
Jan 29, 2017·Environmental Science and Pollution Research International·Laura PistelliMeri Barbafieri
Feb 28, 2020·International Journal of Environmental Research and Public Health·Yafei WangChunlan Tang
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina PiscopoCaterina Manna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.